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Occurrence of Antibiotics in the Environment
Seifrtová, Marcela ; Solich, Petr (advisor) ; Čáslavský, Josef (referee) ; Montenegro, Maria da Conceiçãro Branco (referee)
5 ABSTRACT Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Marcela Seifrtová Supervisor: Prof. RNDr. Petr Solich, CSc. Prof. Angelina Pena, Ph.D. Title of Doctoral Thesis: Occurrence of antibiotics in the environment The occurrence of pharmaceuticals in the environment is a growing concern. The pharmaceuticals are developed to have biological effects, and because of their biological and physico-chemical properties, their release into the environment can have impact in human health and ecosystems. Despite their long half-life, pharmaceuticals are constantly being release into the environment, contributing to a continuous exposure of aquatic ecosystems. The pharmaceuticals are considered as emerging environmental pollutants and the assessment of their environmental risk is acquired. Research on the occurrence, fate and effects is described in the scientific literature, however the data are still insufficient. Antibiotics are an important class of pharmaceuticals widely used in human and veterinary medicine. The main problem associated with their presence in the environment is the development of mechanisms of resistance by bacteria, leading to the development of multi-resistant bacteria, which may put at risk public health in terms of...
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