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Usage of flow through cell dissolution method for medical preparations with controlled release
 Milerová, Romana ; Rabišková, Miloslava (advisor) ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: prof. PharmDr. Miloslava Rabišková, CSc. Student: Romana Milerová Title of Thesis: Usage of flow through cell dissolution method for medical preparations with controlled release Dissolution studies are a very effective tool for easy and efficient obtaining information about the behavior of medical preparations in the human body. For decades, it has been successfully used in the development of dosage forms as well as in quality control for batch quality control during routine production. In vitro dissolution testing has become even more important because the in vitro/ in vivo correlation is based on their results. This diploma thesis presents the usage of flow through cell dissolution method for medical preparations with controlled release. This work describes both the specific description of the flow thorough cell method and the test methods specified in the Czech Pharmacopoeia which uses it. Next, follows a breakdown according to the dosage forms together with a description of the modification of the flow through methods. Since the flow through cell was originally designed for oral controlled release drug formulations, the most extensive part of the work is focused on this route of...
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