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National Repository of Grey Literature

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The influence of acute and chronic application of olanzapine on brain perfusion in rat Dražanová, Eva ; Rudá-Kučerová, J. ; Krátká, Lucie ; Horská, K. ; Kotolová, H. ; Štark, T. ; Babinská, Z. ; Micale, V. ; Starčuk jr., Zenon Olanzapine belongs to the first choice drug in treatment of schizophrenia. We focused on blood perfusion changes inducted by acute and chronic application of olanzapine in healthy animals and MAM altered animals. We detectet significant lower perfusion of cerebral cortex in acute and chronic olanzapine treated animals. We susspect that it could be due to altered neurotransmiter regulation caused by olanzapine. Detailed record

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