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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Prediction of the Effect of Mutation on Protein Solubility
 Marko, Július ; Smatana, Stanislav (referee) ; Hon, Jiří (advisor)
Protein solubility is a key problem in production of functional proteins. Prediction of the effect of mutation on protein solubility could save a lot of time and money, as it would provide in silico prediction of solubility enhancing mutations before performing deep mutational scanning in laboratory. In this work, new predictor of the effect of mutation on protein solubility SoluProtMut is introduced that is based on machine learning methods. Most of the existing predictors predict the effect from the amino acid sequence. In addition to the sequence, the tool presented in this work also uses the spatial structure of the protein, which can significantly increase it's accuracy.
Detailed record
Prediction of the Effect of Mutation on Protein Solubility
 Marko, Július ; Smatana, Stanislav (referee) ; Hon, Jiří (advisor)
Protein solubility is a key problem in production of functional proteins. Prediction of the effect of mutation on protein solubility could save a lot of time and money, as it would provide in silico prediction of solubility enhancing mutations before performing deep mutational scanning in laboratory. In this work, new predictor of the effect of mutation on protein solubility SoluProtMut is introduced that is based on machine learning methods. Most of the existing predictors predict the effect from the amino acid sequence. In addition to the sequence, the tool presented in this work also uses the spatial structure of the protein, which can significantly increase it's accuracy.
Detailed record

See also: similar author names
1 Marko, Jakub
5 Marko, Jan
3 Marko, Juraj
5 Marko, Ján
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