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Synthesis of substituted oxadiazoles with potential antimycobacterial activity
Mészárosová, Daniela ; Karabanovich, Galina (advisor) ; Krátký, Martin (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Author: Daniela Mészárosová Supervisor: Ing. Galina Karabanovich, Ph.D. Title of Diploma Thesis: Synthesis of substituted oxadiazoles with potential antimycobacterial activity Tuberculosis is an infectious disease caused by mycobacteria Mycobacterium tuberculosis, which is one of the top ten causes of death worldwide. According to the World Health Organization, 10.4 million new cases were reported in 2016 and 1.7 million people died of this disease (including 0.4 million people with HIV). Treatment of tuberculosis caused by drug-susceptible strains of M. tuberculosis is very successful, with up to 82% of patients cured. However, a major problem is the therapy of patients with drug resistant strains of M. tuberculosis. Multidrug-resistant tuberculosis (MDR-TB) is a TB that cannot be cured by isoniazid (INH) or rifampicin (RIF), the two most effective first-line antituberculotics. In this case, TB is treated with second-line antituberculotics, which should be administered for up to two years. However, according to statistics, only 32.2% of patients with MDR-TB are successfully cured in the European Union. Therefore, it is important to look for and develop new drugs that act on MDR-TB and can help...
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