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Mitochondrial function in skeletal muscle of critically ill
Urban, Tomáš ; Duška, František (advisor) ; Bořilová Linhartová, Petra (referee) ; Lipový, Břetislav (referee)
Aerobic phosphorylation in the mitochondria is an essential source of ATP for the functioning of higher organisms. It can be assumed that in critically ill patients, alterations in mitochondrial function are not only a para-phenomenon but also a cause of metabolic dysfunction and skeletal muscle function. In addition, critically ill patients are given drugs that facilitate care but may have unwanted side effects. Among these is the widely used diisopropylphenol, i.e. propofol. However, there is increasing evidence that propofol can induce propofol infusion syndrome, leading to mitochondrial dysfunction and failure, which can lead to the death of the patient. The research question in our project was whether there are differences in mitochondrial function compared to a control group in critically ill patients at different stages of the disease, and whether there is a difference between the group rehabilitating with the FES-CE device, i.e. functional electrical stimulation assisted ergometry, and the group with standard rehabilitation. Furthermore, we aimed to determine whether and how different parts of the respiratory chain are inhibited during propofol administration. In a subgroup of patients enrolled in a prospective randomized controlled trial, The Effect of Functional Electrical...
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