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Employing Computer-Assisted Practise of Grammar School Biology Curriculum
Krump, Ondřej ; Mourek, Jan (advisor) ; Stratilová Urválková, Eva (referee)
Growing knowledge in the field of cognitive science can significantly improve the way we learn. Several methods and principles are being repeatedly confirmed by numerous studies as effective for learning. They include spaced repetition, test-enhanced learning, and desirable difficulty principle. With the continual spreading of ICT technologies, diverse software is being developed as well, some of which more and some of which less successfully employs the methods and principles outlined. Memrise, Purpose Games and Drill and Skill, web platforms which are examined in this thesis, belong to this software family. In the first phase, i conducted several interviews with teachers who were using Drill and Skill as part of their science teaching at elementary schools and a junior grammar school (all of them were teaching children approx. 11-15 years old). After this, i worked with a class from a grammar school (age around 16). i made several groups of educational games to help the students practice the topics studied in their biology lessons. Each group of games was reviewed during a group interview. Recordings from these interviews as well as from the interviews with the teachers were transcribed and these transcripts underwent qualitative analysis, which is an important part of the thesis. Drawing on all...
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Employing Computer-Assisted Practise of Grammar School Biology Curriculum
Krump, Ondřej ; Mourek, Jan (advisor) ; Stratilová Urválková, Eva (referee)
Growing knowledge in the field of cognitive science can significantly improve the way we learn. Several methods and principles are being repeatedly confirmed by numerous studies as effective for learning. They include spaced repetition, test-enhanced learning, and desirable difficulty principle. With the continual spreading of ICT technologies, diverse software is being developed as well, some of which more and some of which less successfully employs the methods and principles outlined. Memrise, Purpose Games and Drill and Skill, web platforms which are examined in this thesis, belong to this software family. In the first phase, i conducted several interviews with teachers who were using Drill and Skill as part of their science teaching at elementary schools and a junior grammar school (all of them were teaching children approx. 11-15 years old). After this, i worked with a class from a grammar school (age around 16). i made several groups of educational games to help the students practice the topics studied in their biology lessons. Each group of games was reviewed during a group interview. Recordings from these interviews as well as from the interviews with the teachers were transcribed and these transcripts underwent qualitative analysis, which is an important part of the thesis. Drawing on all...
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Mitochondrial proteases and their role in biogenesis of mitochondria
Krump, Ondřej ; Stibůrek, Lukáš (advisor) ; Pecina, Petr (referee)
Mitochondria are organelles of endosymbiotic origin responsible for many cellular functions, including bioenergetics, biosynthesis and apoptosis. Regulated protein turnover is crucial for proper mitochondrial function. It is controlled by cellular proteolytic system, especially by its mitochondrial part. This mitochondrial proteolytic system is comprised of severeal groups of proteases. The best characterized AAA+ proteases constitute hollow oligomeric complexes, in which the proteolytic domains are localized. Access to these domains is dependent on unfolding - an energy-consuming process driven by ATP hydrolysis mediated by ATPase domains of AAA+ protein. The main function of AAA proteases is proteolytic degradation of proteins, a part of quality control system of mitochondrial proteins. AAA proteases are localized freely in mitochondrial matrix (Lon and ClpXP), or anchorred in the inner membrane (i-AAA and m-AA). Processing peptidases cleave off the mitochondrial targetting sequences of nuclearly encoded mitochondrial proteins. Oligopeptidases cleave peptides produced by processing and proteolytical degradation to single amino acids. Incorrect function of various components of mitochondrial proteolytical system is implicated in several diseases, including certain forms of hereditary spastic paraplegia...
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