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Method Study of Diastereomeric 3-Arylflavins Preparation
Solnička, Ondřej ; Kotoučová, Hana (advisor) ; Budka, Jan (referee)
The presented diploma thesis is built on my bachelor thesis and deals with the study of preparation of ortho-substituted 3-phenylflavins. The target is prepration of 3-ortho-tolylflavin and 3-ortho-tolylflavin-N-oxide and their potential transformation to diastereomeric ortho-substituted flavin-amides or flavin-esters. Obtained substances could be tested as potential catalysts for redox reactions, especially for enantioselective sulfoxidations.
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Constructivism in Organic Chemistry Nomenclature Education
Musilová, Lucie ; Rusek, Martin (advisor) ; Kotoučová, Hana (referee)
Organic chemistry nomenklature is one of the most importatnt matter of chemistry education. Its last change occured in 1993. The available high school chemistry textbooks, which have been analized, deal with nomenclature very briefly. They use the instructive educational approach which is mostly based on deduction. However, it is contrary to the contemporary attitude of education. This is the substantiation for creating the alternative procedure and verifying the availability in practice. This work presents two worksheets that deal with the introduction of the organic chemistry nomenclature. This is the substantiation of creating the alternative procedure and verifying the availability practice. This metodology has been assesed by teachers of grammar schools. Due to the reactions, the material was positively evaluated not only by students but also by teachers themselves. Remarks acquired by piloting were incorporated into the material and can therefore be tested on a larger representative sample.
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Optimization of photochemical hydrogen peroxide preparation
Mesnerová, Iveta ; Čapek Adamec, Martin (advisor) ; Kotoučová, Hana (referee)
The thesis topic: Optimization of photochemical preparation of hydrogen peroxide for laboratory of inorganic chemistry Abstract: This Bachelor thesis deals with compound of hydrogen and oxygen, hydrogen peroxide. The theoretical part of thesis deals with basic physical and chemical characteristic of hydrogen peroxide, its preparation and last but not the least its production. The practical part of thesis deals with two main laboratoř preparations of hydrogen peroxide. First, from barium peroxide sequential reaction with hydrochloric acid, sulphuric, carbonate leader. Second, from anthraquinone dissolved in toluene by photochemical reduction isopropylalcohol and following oxidation mixture of air oxygen. The aim of thesis is implementation of those two methods, finding out the pros and cons and their comparison mainly from the point of preparation effectivness and possibility of use in laboratories of inorganic chemistry. Keywords: hydrogen peroxide, anthraquinone, photochemical reduction, toluene, isopropylalcohol
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Attempt to Prepare N-(4-oxazolin-2-ylphenyl)barbituic acid
Sika, Jan ; Kotoučová, Hana (advisor) ; Liška, František (referee)
Presented bachelor thesis is a part of broader topic of preparation and utilization of flavines and flavin salts in organo-catalysis. Primarily it deals with their utilization in the role of catalyst in enantioselective oxidations. Original purpose of this thesis was to prepare N-[4-(oxazolinu-2-yl)phenyl]barbituric acid 1. This experiment was supposed to prove a possibility of similarly substituted barbituric acids preparation and their further use in antropoizomer flavines and flavin salts synthesis. Although the original substance preparation proved to be unsuccessful the work results in the a successful preparation of one its intermediates N-[4-(oxazolin-2yl)phenyl]-methylcarbamate 25 which is a brand new substance and which was successfully characterized.
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Preparation of N-(2-oxazoline-2-yl-phenyle)barbituic acid
Strnadová, Iveta ; Kotoučová, Hana (advisor) ; Čapek Adamec, Martin (referee)
In my bachelor thesis I dealed with preparation of N-(2-oxazoline-2-ylfenyl)barbituic acid by condensation of N-(2-oxazolin-2-ylfenyl) urea with malonic acid in the presence of acetic acid and acetic anhydride and condensation of the N-substituted urea with diethylmalonate in the presence of sodium ethoxide, too. Original substance for the preparation of N-(2-oxazoline-2-ylfenyl) urea was 2-aminophenyle-2-oxazolin, which was prepared from 2-aminobenzonitrile.
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Verification of flavinium salts reactivity with N- and O-nucleophiles for eventual transformation of boronic acids to corresponding amines
Honskusová, Linda ; Kotoučová, Hana (advisor) ; Holakovský, Roman (referee)
Presented diploma thesis follows the long-term study running at the Department of Organic Chemistry at the University of Chemistry and Technology Prague in the field of using flavinium salts as catalysts of oxidation reactions. The aim was to verify the reactivity of flavinium salt 13 with different types of O- and N-nucleophiles by monitoring of the corresponding C4a-adducts formation. In the thesis a simple alloxazinium salt 13 and one of the nucleophiles (hydroxylamine 25) were prepared. According to the results obtained from the UV-VIS measurements nucleophile 25 is the only one of the newly tested wchich formed desired C4a-adduct 13d with alloxazinium salt 13. KEYWORDS flavinium salt, nucleophile, C4a-adduct, organocatalysis, IBSE
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Verification of flavinium salts reactivity with N- and O-nucleophiles for eventual transformation of boronic acids to corresponding amines
Honskusová, Linda ; Kotoučová, Hana (advisor) ; Holakovský, Roman (referee)
Presented diploma thesis follows the long-term study running at the Department of Organic Chemistry at the University of Chemistry and Technology Prague in the field of using flavinium salts as catalysts of oxidation reactions. The aim was to verify the reactivity of flavinium salt 13 with different types of O- and N-nucleophiles by monitoring of the corresponding C4a-adducts formation. In the thesis a simple alloxazinium salt 13 and one of the nucleophiles (hydroxylamine 25) were prepared. According to the results obtained from the UV-VIS measurements nucleophile 25 is the only one of the newly tested wchich formed desired C4a-adduct 13d with alloxazinium salt 13. KEYWORDS flavinium salt, nucleophile, C4a-adduct, organocatalysis, IBSE
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