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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Mechanism of the vasorelaxant effect of biochanin A studied ex vivovon isolated rat aorta
 Katiová, Diana ; Pourová, Jana (advisor) ; Trejtnar, František (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxikology Consultant: PharmDr. Jana Pourová, Ph.D. Consultant specialist: Mgr. Thomas Migkos Student: Diana Katiová Title of Thesis: Mechanism of the vasorelaxant effect of biochanin A studied ex vivo on isolated rat aorta Flavonoids are secondary plant metabolities which are known for thein wide range of effects. Many of them have beneficial effects on the human organism. Thay have anti-inflammatory properties, antioxidant activity and positive effect on cardiovascular system. The main aim of this thesis was to determine possible vasorelaxant mechanisms of action of selected isoflavonoid biochanin A. The vasorelaxation potential was verified in ex vivo conditions on isolated rat aortic rings. The results has confirmed dose-dependent induced vasodilatation. Our experiments confirm that the vasodilatatory effect of biochanin A is independent on the function of endotel. Beside that the experimental part of this thesis is dealing with the effect of this substance on Ca2+ channels of L-type in the plasma membrane and whether vasorelaxant effect is dependent on extracelullar Ca2+ . Our results confirm that similarly as nifedipine biochanin A blocks these channels as well. Moreover biochanin A in the medium without...
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The influence of external lubrication on the compaction process and properties of microcrystalline cellulose tablets
 Katiová, Diana ; Ondrejček, Pavel (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technolgy Consultant: PharmDr. Pavel Ondrejček, Ph.D. Student: Diana Katiová Title of Thesis: The influence of external lubrication on the compaction process and properties of microcrystalline cellulose tablets The main aim of this diploma thesis was to determine the effect of internal and external lubrication on compression process and properties of prepared tablets. During this work three materials were used. Microcrystalline cellulose was used as a model filler and Syloid with magnesii stearas as lubricants. The flow properties of tested mixtures before compression were determined by using the angle of respose and flow through orifice. Compressibility of materials was studied by using force displacement method and by parameters of three-exponential equation which describe the phases of compression process. These phases are precompression, elastic deformation and plastic deformation. At the same time the effect of external lubrication on the radial strenght and the disintegration time of prepared teblets by two different compaction forces were tested. The results proved that internal addition of lubricants has a positive effect on flow properties of mixtures which influenced the parameters of force displacement...
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