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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Effect of radical surgery and experimental consolidation therapy on immunological parameters in patients with ovarian carcinoma.
 Brtnický, Tomáš ; Rob, Lukáš (advisor) ; Zikán, Michal (referee) ; Jurga, Ľudovít (referee)
The incidence of ovarian carcinoma in the Czech Republic is one of the highest in the EU. The five year survival rate of all stages is approximately 40%. The mortality still remains high globally, despite the efforts of diagnostic procedures and modern treatment. After ending the course of chemotherapy, a completely successful clinical response can be achieved in the early stages (stage I. a II.) in almost 100% of patients. However in 20-40 % it is unfortunately impossible to completely eliminate all tumour cells resistant to chemotherapy and almost a third of women have relapses. Today in the late stages (III. a IV.) more than 70 % of cases result in complete clinical remission; however within 2 years more than 50 % of women from this group suffer from relapses. The relaps of disease results from the activation of a chemoresistant clone of malignant cells. Those cell populations that aren't detectable using investigation methods are marked as minimal residual disease. The issue has been divided into three areas. In the first we monitored the amount of regulatory T-cells in peripheral blood of patients with ovarian cancer. In the second we monitored the dynamics of the immune infiltrate, depending on the stage of the disease. In the third, we tested various types of cytostatics in their ability to...
Detailed record
Effect of radical surgery and experimental consolidation therapy on immunological parameters in patients with ovarian carcinoma.
 Brtnický, Tomáš ; Rob, Lukáš (advisor) ; Zikán, Michal (referee) ; Jurga, Ľudovít (referee)
The incidence of ovarian carcinoma in the Czech Republic is one of the highest in the EU. The five year survival rate of all stages is approximately 40%. The mortality still remains high globally, despite the efforts of diagnostic procedures and modern treatment. After ending the course of chemotherapy, a completely successful clinical response can be achieved in the early stages (stage I. a II.) in almost 100% of patients. However in 20-40 % it is unfortunately impossible to completely eliminate all tumour cells resistant to chemotherapy and almost a third of women have relapses. Today in the late stages (III. a IV.) more than 70 % of cases result in complete clinical remission; however within 2 years more than 50 % of women from this group suffer from relapses. The relaps of disease results from the activation of a chemoresistant clone of malignant cells. Those cell populations that aren't detectable using investigation methods are marked as minimal residual disease. The issue has been divided into three areas. In the first we monitored the amount of regulatory T-cells in peripheral blood of patients with ovarian cancer. In the second we monitored the dynamics of the immune infiltrate, depending on the stage of the disease. In the third, we tested various types of cytostatics in their ability to...
Detailed record

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