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Changes in preferences for heterozygosity in MHC genes across the menstrual cycle
Ptáčková, Kateřina ; Havlíček, Jan (advisor) ; Janotová, Kateřina (referee)
5 Abstract Products of major histocompatibility complex (MHC) plays key role in immune system of vertebrates. Prior studies on different vertebrate species show, that heterozygosity in MHC genes is linked to more efficient immune system and preferred in mate choice. Results of human studies are ambivalent, which can be due to the effect of some modulating factors like reproductive status. Therefore, our aim was to test heterozygosity related preferences in faces, odor and voice across menstrual cycle. Our sample consisted of 51 men and 52 women, from which 23 used hormonal contraception and 29 had natural cycle. They were genotyped in -A, -B and -DR alleles. All odor stimuli, face photos and voice records were rated on seven-point scale in both follicular and luteal phase. Repeated measures ANOVA was used for the analysis. Changes in ratings across the menstrual cycle and heterozygosity were most discernible on voice ratings. Voices of homozygous males were rated more attractive than voices of heterozygous males especially in follicular phase. Similar shift to higher ratings in follicular phase was manifested in ratings of homozygous male faces, but the difference between homozygous males and heterozygous males was not significant. Women with natural cycle also rated voices higher in their follicular phase...
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Mechanisms of microbiota regulation during the estrous cycle of the house mouse.
Dodoková, Alica ; Stopková, Romana (advisor) ; Janotová, Kateřina (referee)
There is a very few papers to provide an overview of the characteristics of the estrous cycle, the relationship of the estrous cycle to physiological manifestations such as the pH of the vaginal environment, as well as the dynamics of the vaginal microbiota in wild mice. The aim of this thesis is to contribute to the understanding of the dynamic relationship between external influences and the physiology of the female reproductive system, to develop a reliable methodology for measuring the pH of the vaginal microenvironment in mice as well as to quantify the overall abundance of some bacterial taxons by comparing sequencing and qPCR methods. The results suggest that the physical presence of the male in the cage has the most significant effect on the prolongation of the estrus phase, in contrast to non-significant olfactory stimulation of the urine. Fluctuation in the pH of the vaginal environment have also been shown to be cyclic, and the qPCR method shows that the composition of the vaginal microbiota, during the estrus phase, differs significantly from other phases of the estrous cycle, as we confirmed by 16S rRNA sequencing. Thus, these results provide a comprehensive view of the variability of the estrous cycle with an emphasis on the variability of the vaginal microbiota and the change in the...
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Study of chemical communication in the house mouse: a proteomic approach
Janotová, Kateřina ; Stopka, Pavel (advisor) ; Piálek, Jaroslav (referee) ; Vošlajerová, Barbora (referee)
Chemical communication of the house mouse is similarly as in other mammals, substantially complex and influence every social ineraction between individuals. Important part of mouse chemical signalling system is Major Urinary Protein complex (MUP). These proteins are known as pheromone-carriers that prolong longevity of the pheromones by retarding their evaporation from the scent mark. Their other role in chemical communication is direct signalling which is mediated by VNO. MUP have been shown to trigger both behavioural and physiological effects in recipient. Proteins belonging to the same family (lipocalins) as MUPs, have been found in other, mainly rodent, species. Although the information about these urinary lipocalins are, with exception of mouse, very limited, it is likely that their roles relies in chemical communication. The Ph.D. thesis is related to the urinary proteins in the house mouse and Mastomys coucha. Thesis contains four chapters represented by three published and one submitted manuscript. One aim of the thesis is to provide information about these proteins in the subspecies Mus musculus musculus which is widespread in the Czech Republic and which is much less studied when compared to Mus musculus domesticus. The part of Ph.D thesis is a review publication which summarizes recent...
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Changes in preferences for heterozygosity in MHC genes across the menstrual cycle
Ptáčková, Kateřina ; Havlíček, Jan (advisor) ; Janotová, Kateřina (referee)
5 Abstract Products of major histocompatibility complex (MHC) plays key role in immune system of vertebrates. Prior studies on different vertebrate species show, that heterozygosity in MHC genes is linked to more efficient immune system and preferred in mate choice. Results of human studies are ambivalent, which can be due to the effect of some modulating factors like reproductive status. Therefore, our aim was to test heterozygosity related preferences in faces, odor and voice across menstrual cycle. Our sample consisted of 51 men and 52 women, from which 23 used hormonal contraception and 29 had natural cycle. They were genotyped in -A, -B and -DR alleles. All odor stimuli, face photos and voice records were rated on seven-point scale in both follicular and luteal phase. Repeated measures ANOVA was used for the analysis. Changes in ratings across the menstrual cycle and heterozygosity were most discernible on voice ratings. Voices of homozygous males were rated more attractive than voices of heterozygous males especially in follicular phase. Similar shift to higher ratings in follicular phase was manifested in ratings of homozygous male faces, but the difference between homozygous males and heterozygous males was not significant. Women with natural cycle also rated voices higher in their follicular phase...
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Life-guard Swimming in Various Examples of Swimming Instruction
Janotová, Kateřina ; Miler, Tomáš (advisor) ; Čechovská, Irena (referee)
Magdalény Rettigové 4, 116 39 Praha 1 tel.: +420 221 900 111 www.pedf.cuni.cz IČ 00216208 DIČ CZ00216208 Dle čl. 4 Opatření rektora č. 6/2010 o Zpřístupnění elektronické databáze závěrečných prací http://www.cuni.cz/UK-3470.html a čl. 1 Opatření děkana 17/2010 se z časového hlediska závěrečné práce dělí do tří skupin: a. "nové práce", tj. práce odevzdávané k obhajobě počínaje 29. 9. 2010, b. "starší práce", tj. práce odevzdané k obhajobě od 1. 1. 2006 do 28. 9. 2010, c. "práce před rokem 2006", tj. práce odevzdané k obhajobě před 1. 1. 2006. V tomto případě jde o "starší práci" odevzdanou k obhajobě od 1. 1. 2006 do 28. 9. 2010. Omlouváme se, ale dokument není k dispozici.
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