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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Imunological and histological methods in Huntington's disease research
 Jandurová, Patrícia ; Němečková, Ivana (advisor) ; Rathouská, Jana (referee)
Author: Patrícia Jandurová Title of thesis: Imunologické a histologické metody ve výzkumu Huntingtonovy nemoci Bachelor thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Study course: Medical laboratory technician Huntington's disease (HD) is a severe autosomal inherited neurodegenerative disorder that affects individuals regardless of gender. This disorder is caused by an expansion of CAG repeats in huntingtin gene, that is expressed in almost all tissues. Mutant protein causes a neuron degeneration in a brain of HD pacients which leads to a motor abnormalities and personality decay. The disease developes in the presence of a mutation in one of two huntingin alleles. The risk of transmission of disease for the direct descendants is 50%. This disease is very malign because of its late onset. An adequate therapy does not exist yet, but a lot of research teams focus on designig a suitable medical treatment. This work is devoted to the description of Huntington's disease and is focused on immunological and histological methods used in animal model experimental studies. Particular techniques are described and the results are supported with figures. Key words: Huntington's disease, CAG repeat, immunological and histological methods, animal model
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