National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Genetic changes in the regulatory regions of NMDA receptors and their association possible connection the development of schizophrenia
Hrychová, Šárka ; Balík, Aleš (advisor) ; Moravcová, Radka (referee)
Schizophrenia is a serious neuropsychiatric disorder with a severe impact on patients' lives. Based on the experiments in animal models and also from the observations of the influence of the drug in humans it was concluded that the decreased activity of N-methyl-D- aspartate (NMDA) receptor gives rise to behaviour that is associated with the clinical manifestation of schizophrenia. Therefore, it is hypothesized that genetically determined variations in NMDA receptor activity contributes to the emergence and development of schizophrenia. The aim of this bachelor thesis is to summarize current knowledge on genetic alternations particularly in the regulatory regions of NMDA receptors in schizophrenia. Key words: schizophrenia, NMDA receptor, genetic changes
Prevention and treatment of pressure ulcers in nursing Home for elderly Milevsko
HRYCHOVÁ, Šárka
Background methods: Appearance of decubitus is a main indicator of therapeutic and nursing care quality and is monitored carefully. However, they supervence in despite of high-quality and professional care of nursing staff, because there are factors, which we cannot influence while decubitus emergence. The main purpose of research was to map the preventative and nursing care of clients with the risk of decubitus and with it, find out if the care is in high-quality and possibly debunk absences and deduce a treatment for work experience.Methodics: The research was done by quantitative method, by technique of secondary analysis of data. Analytic studies check if there is a relation among the watched features. The data was received from verified and enclosed nursing documentation of Home for senior citizens in Milevsko from years 2010 and 2011. Procured data was afterwards elaborated by descriptive statistics by Microsoft Excel and SPSS program. Validity of hypotheses was tested via Chí quadrate test. Research aggregate created nursing documentation of Home for senior citizens in Milevsko. This establishment has 36 beds and during the year 2010 and 2011, 85 clients were accomodated here. Consistent with the first research purpose "To map the high-risk factors, which increases the probability of decubitus emergence." was evaluated nursing documentation of 85 clients. Consistent with the second research purpose "To find out, the precautionary measures belittling the risk of decubitus emergence of vulnerability client group." was evaluated by nursing documentation of 54 clients. Consistent with the third research purpose "To map the nursing intervention of clients with decubitus." was evaluated by nursing documentation of 10 clients.Results: From the research, results arose that there was the risk of decubitus emergence at every client of Home for senior citizens in Milevsko according to directory evaluative Norton scale. The final results demonstrated a high percentage 63,4 % clients who were endangered by the decubitus emergence. After one month, a checking evaluation of the risk of decubitus emergence was made according to directory evaluative Norton scale. The results demonstrated the strong depression of the number of clients with the risk of decubitus emergence or at least the depression of risk. The last part of research was focused on watching the nursing intervention of the client group with decubitus and finding the fruitfulness of the decubitus treatment. The result demonstrated that the treatment was in most cases succesfull and that 80% of clients were healed in four month.Conclusion: The important finding for the nursing staff was the assertion that the provided nursing care in Home for senior citizens in Milevsko has a good standard. Simultaneously, some absences were found like deficient resource of nutritive accessoires, damp healing of wounds, and utilities against decubitus in standard goings. The solving of these absences is to increase accessibility and awareness of professional doctors for resource of the necessary amount of nutritive accessoires, damp healing of wounds, and not to let clients with deficient financial resources to be entirely dependent on out of date medical advancement. Also, not to corrupt treatment and precautionary measures. The next important step is to motivate family members and imply them to take care of their relatives. The research was shortened and offered to censored journal for medical and hospital branch Profese on-line to be published.

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