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Analyses of inverted repeats in human patogen genomes
Hanzlíková, Anna ; Nováčková, Ivana (referee) ; Brázda, Václav (advisor)
Pathogens are organisms that cause various host diseases. These include prions, viruses, bacteria, fungi, protozoa and animals. This bachelor thesis is focused specifically on viruses causing human diseases such as severe respiratory syndromes, liver diseases or cervical cancer. The aim of this bachelor thesis was to characterize the presence and location of inverted repeats in the genomes of organism using the web application Palindrome analyzer. Four viruses were selected, two of them are from the group of DNA viruses and two from the group of RNA viruses. In view of the outbreak of a pandemic in early 2020 caused by virus SARSCoV-2, is included in this bachelor thesis. Thus, SARS-CoV and SARS-CoV-2 were selected from RNA viruses and hepatitis B virus and human papillomavirus were selected from the DNA viruses. The sequences of the viral genomes were obtained from the NCBI (National Center for Biotechnology) database. Then, all four viruses were analyzed for the presence of inverse repeats, their location and size using the Palindrome analyzer, which is available online. The largest genome was SARS-CoV-2 of 29 903 bp, which also had the most inverse repeats.
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Analyses of inverted repeats in human patogen genomes
Hanzlíková, Anna ; Nováčková, Ivana (referee) ; Brázda, Václav (advisor)
Pathogens are organisms that cause various host diseases. These include prions, viruses, bacteria, fungi, protozoa and animals. This bachelor thesis is focused specifically on viruses causing human diseases such as severe respiratory syndromes, liver diseases or cervical cancer. The aim of this bachelor thesis was to characterize the presence and location of inverted repeats in the genomes of organism using the web application Palindrome analyzer. Four viruses were selected, two of them are from the group of DNA viruses and two from the group of RNA viruses. In view of the outbreak of a pandemic in early 2020 caused by virus SARSCoV-2, is included in this bachelor thesis. Thus, SARS-CoV and SARS-CoV-2 were selected from RNA viruses and hepatitis B virus and human papillomavirus were selected from the DNA viruses. The sequences of the viral genomes were obtained from the NCBI (National Center for Biotechnology) database. Then, all four viruses were analyzed for the presence of inverse repeats, their location and size using the Palindrome analyzer, which is available online. The largest genome was SARS-CoV-2 of 29 903 bp, which also had the most inverse repeats.
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