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Účinek bisfenolu S na vybrané krevní parametry potkanů
HLATKÁ, Tereza
Bisphenol S (BPS) is an organic substance which has replaced significantly industrially used bisfenol A (BPA). Eventhough BPS shows higher tolerance against physical influence, there have been registered leaks from the final products and there is a posibility of wather, food and environtment contamination. Until now the BPS has been, just like BPA, mostly connected with disruption of the reproductive system of human and animals. The aim of the bachelor thesis was to determinate whether a ten weeks oral exposure to BPS (50 ?g, 100 mg/kg live weight/day) leads to disturbance in selected haematological parameters (erythrocyte count (RBC), haemoglobin concentration (HGB), haematocrit value (HCT), mean corpuscular volume (MCV), erythrocyte haemoglobin concentration (MCHC), mean corpuscular haemoglobin (MCH), total leucocytes, percentage of granulocytes, lymphocytes and monocytes). Eighteen Wistar Han rats were enrolled in the experiment and they were divided into three groups (control group, 50 ?g BPS, 100 mg BPS). Dissolved BPS in sunflower oil was given to the experimental groupts by a gavage. Blood was collected through cardiac puncture and analyzed using an automated hematology analyser. In the particular study, we found out a nonsignificant decrease of HGB and nonsignificant increase of MCV and MCH in experimental animals. BPS also led to a nonsignificant changes in the number of leukocytes (increase in the total number of leukocytes) and it led to a changes in the number of individual types of the white blood cells representation (increase in the percentage of granulocytes, decrease in lymphocytes). More significant effect was observed in 50 ?g BPS group. Our results did not conclusively proved the negative effect of BPS on the selected blood parameters of rats.
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