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Sleep disorder as a risk factor for the development of diabetes mellitus type 2
Gorbunovová, Eva ; Kudláčková, Zděnka (advisor) ; Fikrová, Petra (referee)
Author: Eva Gorbunovová Title: Sleep disorder as a risk factor for the development of diabetes mellitus type 2 Diploma thesis Charles' University in Prague, Faculty of Pharmacy in Hradec Kralove Field: Pharmacy Background: The aim of this thesis with the help of available domestic and foreign literature is to analyze the impact of sleep disorders on the development of Diaberes Mellitus type II. Main findings: In our work we show the basic characteristics of sleep disorders and diabetes mellitus. We focused on some of the factors which were demonstrated to affect the metabolism. It was found that chronic sleep disorders lead to the increased production of cortisol which in a long term affects the metabolism of carbohydrates, fats and proteins and also influences the development of insulin resistance. As a result of sleep disorders is also the reduction of the concentration of leptin, resulting in increased appetite. Studies conducted on mice show that due to increased levels of ghrelin, as a result of sleep disorders, there is also an increase in food intake. Increased levels of ghrelin increases the secretion of growth hormone and orexins, hormones that also affect metabolism. Sleep disorders can affect the levels of cytokines, especially, IL-1, IL-6 and TNF-α, which are produced in the organism in...
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Comparison of copper ion chelation by benzoic acids
Gorbunovová, Eva ; Karlíčková, Jana (advisor) ; Spilková, Jiřina (referee)
Charles University Faculty of Pharmacy Hradec Králové Department of Pharmaceutical Botany Candidate: Mgr. Eva Gorbunovová Supervisor: PharmDr. Jana Karlíčková, Ph.D. Title of Rigorous Thesis: Comparison of copper ion chelation by benzoic acids Copper is the third most widespread element in the human body. It is necessary to maintain the homeostasis of the organism, the proper functioning of enzymes, participate in various metabolic pathways. Benzoic acid and its derived acid belong to a group of phenolic compounds that are formed by the metabolic processing of flavonoids in the human body and can have antioxidant, anti-inflammatory and antitumor effects that could be used in medicine. In this rigorous thesis, the copper-chelating activity of six benzoic acids was tested at different pH values using spectrophotometric methods using hematoxylin and bathocuproinedisulfonic acid disodium salt as indicators. The top copper-chelating activity with cupric ions using hematoxylin and the bathocuproinedisulfonic acid disodium salt and copper-chelating activity with cuprous ions using bathocuproinedisulfonic acid disodium salt showed two acids, namely 2,4- dihydroxybenzoic acid and 2-hydroxy-4-methoxybenzoic acid. Key words: Phenolic acids, benzoic acid derivatives, copper, chelating, bathocuproinedisulphonic...
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Comparison of copper ion chelation by benzoic acids
Gorbunovová, Eva ; Karlíčková, Jana (advisor) ; Spilková, Jiřina (referee)
Charles University Faculty of Pharmacy Hradec Králové Department of Pharmaceutical Botany Candidate: Mgr. Eva Gorbunovová Supervisor: PharmDr. Jana Karlíčková, Ph.D. Title of Rigorous Thesis: Comparison of copper ion chelation by benzoic acids Copper is the third most widespread element in the human body. It is necessary to maintain the homeostasis of the organism, the proper functioning of enzymes, participate in various metabolic pathways. Benzoic acid and its derived acid belong to a group of phenolic compounds that are formed by the metabolic processing of flavonoids in the human body and can have antioxidant, anti-inflammatory and antitumor effects that could be used in medicine. In this rigorous thesis, the copper-chelating activity of six benzoic acids was tested at different pH values using spectrophotometric methods using hematoxylin and bathocuproinedisulfonic acid disodium salt as indicators. The top copper-chelating activity with cupric ions using hematoxylin and the bathocuproinedisulfonic acid disodium salt and copper-chelating activity with cuprous ions using bathocuproinedisulfonic acid disodium salt showed two acids, namely 2,4- dihydroxybenzoic acid and 2-hydroxy-4-methoxybenzoic acid. Key words: Phenolic acids, benzoic acid derivatives, copper, chelating, bathocuproinedisulphonic...
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Sleep disorder as a risk factor for the development of diabetes mellitus type 2
Gorbunovová, Eva ; Kudláčková, Zděnka (advisor) ; Fikrová, Petra (referee)
Author: Eva Gorbunovová Title: Sleep disorder as a risk factor for the development of diabetes mellitus type 2 Diploma thesis Charles' University in Prague, Faculty of Pharmacy in Hradec Kralove Field: Pharmacy Background: The aim of this thesis with the help of available domestic and foreign literature is to analyze the impact of sleep disorders on the development of Diaberes Mellitus type II. Main findings: In our work we show the basic characteristics of sleep disorders and diabetes mellitus. We focused on some of the factors which were demonstrated to affect the metabolism. It was found that chronic sleep disorders lead to the increased production of cortisol which in a long term affects the metabolism of carbohydrates, fats and proteins and also influences the development of insulin resistance. As a result of sleep disorders is also the reduction of the concentration of leptin, resulting in increased appetite. Studies conducted on mice show that due to increased levels of ghrelin, as a result of sleep disorders, there is also an increase in food intake. Increased levels of ghrelin increases the secretion of growth hormone and orexins, hormones that also affect metabolism. Sleep disorders can affect the levels of cytokines, especially, IL-1, IL-6 and TNF-α, which are produced in the organism in...
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