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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Significance of mitochondrial DNA in colorectal cancer
 Danešová, Natálie ; Vodenková, Soňa (advisor) ; Polívková, Zdeňka (referee)
Colorectal cancer is the third most commonly diagnosed cancer worldwide and the second leading cause of cancer death. It is a heterogeneous and multifactorial disease, the development of which takes up to 15 years. In addition to genetic risk factors, external, influenceable factors also contribute to the development of the disease. Patients are often diagnosed in the late stages of the disease, which significantly reduces the chances of their successful treatment. It is therefore necessary to identify appropriate screening, diagnostic, prognostic and predictive biomarkers of the disease. Mitochondria are organelles found in almost all eukaryotic cells and their dysfunction is often involved in the development of cancer. Because mitochondria have their own DNA its changes could serve as a potential biomarker for a closer understanding of the pathogenesis and progression of colorectal cancer. The main goal of this bachelor thesis was to summarize previous studies focused on mitochondrial DNA changes in patients with colorectal cancer and their possible use in clinical practise. Keywords: Colorectal cancer; biomarkers; mitochondria; mtDNA
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