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Microelectrode arrays for mioelectronic
Bráblíková, Aneta ; Vala, Martin (referee) ; Salyk, Ota (advisor)
Organic electronic biosensors are developed as suitable devices that can transform electrochemical processes within the cell membrane into an electronic signal and enable to measure electrical activity of excitable cells and tissues both in vitro and in vivo and thus represent valuable alternative to current cell monitoring methods. In this work we focus on the fabrication of electrophysiological sensors based on organic semiconductors printed by the material printing method. Microelectrode arrays (MEAs) are active components of the device, which can monitore cellular activity and above that stimulating cells with electrical pulses. The proposed platform should be used for cytotoxicity of potential drugs especially on cardiac cells (cardiomyocytes). The experimental part focus on specific production processes of platforms, which were prepared in the laboraty with emphasis on biocompatibility and conductivity of device.
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Optimization of printing of organic electronic devices printing for bioelectronics
Bráblíková, Aneta ; Hrabal, Michal (referee) ; Salyk, Ota (advisor)
This bachelor thesis is focused on optimization of printing of organic electronic devices printing for bioelectronics. The main goal of this bachelor thesis is a series of experiments devised to optimize semiconductive structures of PEDOT (semiconductive polymer) and description of the process used in the preparation of organic electrochemical transistors for biosensor by screen printing technology. The research focused on application of bioelectronics, printing technologies, conductive inks suitable for the preparation of OECTs (organic electrochemical tranzistors) and rheological properties of materials. Main conditions tested in the experimental part were temperature, stirring and additon of DMSO (dimethylsulfoxide) into a printing pasted. The evaluated parameters of materials were basic viscoelastic characteristics. At the ent of the thesis have been successfully designed the series of transistors to monitor cell cultures.
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Microelectrode arrays for mioelectronic
Bráblíková, Aneta ; Vala, Martin (referee) ; Salyk, Ota (advisor)
Organic electronic biosensors are developed as suitable devices that can transform electrochemical processes within the cell membrane into an electronic signal and enable to measure electrical activity of excitable cells and tissues both in vitro and in vivo and thus represent valuable alternative to current cell monitoring methods. In this work we focus on the fabrication of electrophysiological sensors based on organic semiconductors printed by the material printing method. Microelectrode arrays (MEAs) are active components of the device, which can monitore cellular activity and above that stimulating cells with electrical pulses. The proposed platform should be used for cytotoxicity of potential drugs especially on cardiac cells (cardiomyocytes). The experimental part focus on specific production processes of platforms, which were prepared in the laboraty with emphasis on biocompatibility and conductivity of device.
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Optimization of printing of organic electronic devices printing for bioelectronics
Bráblíková, Aneta ; Hrabal, Michal (referee) ; Salyk, Ota (advisor)
This bachelor thesis is focused on optimization of printing of organic electronic devices printing for bioelectronics. The main goal of this bachelor thesis is a series of experiments devised to optimize semiconductive structures of PEDOT (semiconductive polymer) and description of the process used in the preparation of organic electrochemical transistors for biosensor by screen printing technology. The research focused on application of bioelectronics, printing technologies, conductive inks suitable for the preparation of OECTs (organic electrochemical tranzistors) and rheological properties of materials. Main conditions tested in the experimental part were temperature, stirring and additon of DMSO (dimethylsulfoxide) into a printing pasted. The evaluated parameters of materials were basic viscoelastic characteristics. At the ent of the thesis have been successfully designed the series of transistors to monitor cell cultures.
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