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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Vliv komensální mikroflóry na indukci slizniční tolerance k alergenu pylu břízy u BALB/c myší
 Kozáková, Hana ; Repa, A. ; Štěpánková, Renata ; Hrnčíř, Tomáš ; Schwarzer, Martin ; Hudcovic, Tomáš ; Tlaskalová, Helena ; Wiedermann, U.
Compared with germ-free mice model, the microflora has no effect on the development of allergic responses or the ability to induce tolerance using a clinical relevant allergen
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Vliv rekombinantní bakterie Lactobacillus plantarum na vývoj pylové alergieL
 Schwarzer, Martin ; Repa, A. ; Wiedermann, U. ; Hrnčíř, Tomáš ; Daniel, C. ; Pot, B. ; Štěpánková, Renata ; Hudcovic, Tomáš ; Tlaskalová, Helena ; Součková, Martina ; Kozáková, Hana
Germfree mice were monocolonized with recombinant Lactobacillus plantarum producing Bet v 1. Subsequently mice were sensitized by intraperitoneal injections to Bet v 1. We found out that monocolonization with recombinant L. plantarum reduced the level of specific Bet v 1 specific IgE antibody and stimulated production of INF-gamma in spleen cells supernatants. We conclude that monocolonization by recombinant L. plantarum shifts the immune response towards Th-1 direction and that it is a promising vaccine candidate against type I allergy
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