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Prediction of Treatment Effect in Solid Tumors
Houfková, Kateřina ; Pešta, Martin (advisor) ; Fiala, Ondřej (referee) ; Šána, Jiří (referee)
Current research of treatment of oncological diseases is focused on the identification of changes that occur in the process of carcinogenesis and on the search for therapeutics that would make it possible to eliminate the manifestation of these changes. Early diagnosis, estimating prognosis, monitoring of the course of the disease and prediction of the effect of treatment are increasingly associated with the determination of appropriate biomarkers. The assessment of predictive biomarkers should become an integral part of treatment decisions and, as a result, help patients to prolong life and improve quality of life. The aim of my thesis was to find prognostic and predictive biomarkers for more effective treatment of cancer patients. In cooperation with a number of clinical departments of the University Hospital in Pilsen, I focused on the research of these biomarkers at the Department of Biology, especially in non-small cell lung cancer, endometrial cancer, colorectal cancer, liver metastases of colorectal cancer, clear cell renal cell carcinoma and sarcomas. We focused on the research of molecules that are involved in the process of carcinogenesis and whose levels in body fluids or directly in tumor tissue would be able to predict further disease development or therapeutic response. Using molecular...
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