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Šejda, Tomáš ; Poledne, Rudolf (advisor) ; Filipovský, Jan (referee) ; Češka, Richard (referee)
Based on the results of our study, we concluded that the degree of brachial artery flow endothelium-dependent dilatation is difficult to evaluate using predefined cut-off points as a single-measurement screening test to indicate endothelial dysfunction. On the contrary, the variation of endothelial function after a defined stimulus (dietary, medication) examined at a predefined interval using an identical protocol can help to assess enhanced or reduced efficacy of endothelium-dependent vasodilatation. In the next study, we demonstrated that a high-fat load applied at a single dose does not significantly affect brachial artery vasoreactivity in young, healthy volunteers after four weeks of low- and high-fat diets. In contrast with atherosclerosis, the effect of hypercholestrolemia on adhesive molecule levels has been a source of controversy. We demonstrated that 3-month therapy with fluvastatin does not decrease cICAM-1 levels despite normalization of cholesterol levels. The implication is cholesterol may not induce endothelial activation by the initial upregulation of this adhesive molecule. Endothelial dysfunction can be considered the initial, functionally relevant stage of atherosclerosis, demonstrable still before morphological changes. In patients with advanced obliterative atherosclerosis,...
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název v anglickém jazyce není uveden
Štulc, Tomáš ; Češka, Richard (advisor) ; Vaverková, Helena (referee) ; Mareš, Jan (referee)
Lipid lowering treatment substantially reduces the risk of cardiovascular diseases. The effects of lipid lowering go far beyond limiting the extent of atheroslcerotic lesions and decreasing the severity of atherosclerotic stenoses. Recently recognised effects of cholesterol on plaque stability, endothelial function, thrombosis, and plaque inflammation have been subject to intensive research during the past two decades. The effect lipid lowering treatment on the various aspects of the plaque development are being investigated in search of novel therapies to reduce the risk of ahterosclerosis. In this work, we examined cell adhesion molecules, microvascular reactivity and metalloproteinase PAPP-A in patients with hypercholesterolemia and investigated the effect of lipid lowering with atorvastatin and LDL-apheresis. Leukocyte and endothelial adhesion molecules mediate leukocyte recruitment into subendothelial space, contributing thus to plaque inflammation. PAPP-A is a protease which has been related to plaque instability and acute coronary events; it's role in stable atherosclerotic lesions hasn't been studied yet Microvascular reactivity is supposed to reflect endothelial function in the microvascular bed; the knowledge of the effect of hyperlipidemia on microvasculature is currently limited. Patients with...
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