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The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy
Ládová, Kateřina ; Matoulková, Petra (advisor) ; Červený, Petr (referee) ; Lukáš, Milan (referee) ; Kolář, Jozef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Mgr. Kateřina Ládová Supervisor: PharmDr. Petra Matoulková, Ph.D.; PharmDr. Magda Vytřísalová, Ph.D. (Consultant) Title of Doctoral Thesis: The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy Introduction and Objective: Medication adherence (MA) is a highly variable factor affecting the response to the therapy. Especially in chronic disease, non-adherence presents a problem that may have health, social, and even economic consequences. Measuring MA is the most often performed by self-reported surveys which enables, among others, their simple application in research as well as in every day clinical practices. Self-reported MA monitoring may contribute to maximizing the effectiveness of pharmacotherapy and minimizing the risk of therapy failure, however, standardization of measuring process is needed. Moreover, some factors such as healthy adherer effect (HAE), which reflect patient health seeking behaviour but cannot be easily monitored, can favourably affect health outcomes. Acquired results may then be incorrectly attributed to drug therapy examined in the study. Hence, the main aims of this doctoral thesis were: 1) to...
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