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National Repository of Grey Literature

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Biopharmaceutical aspects of macromolecular carriers for systemic sublingual drug delivery Berka, Pavel ; Doležal, Pavel (advisor) ; Kubová, Kateřina (referee) ; Kvítek, Libor (referee) Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate Mgr. Pavel Berka Supervisor Doc. RNDr. Pavel Doležal, CSc. Title of Doctoral Thesis Biopharmaceutical aspects of macromolecular carriers for systemic sublingual drug delivery The primary aim of this work was to experimentally verify the hypothesis on sublingual permeation of macromolecules as drug carriers. Literature data about the sublingual route of drug administration and methods of sublingual and buccal membrane processing for in vitro experiments were reviewed for this purpose. The task to design and verify a new methodology of processing and preservation of sublingual membranes suitable for permeation experiments resulted from this literature review. The new methodology of the "flash freezing" membranes uses the prepared membranes with complete epithelial composition, including the lamina propria and part of the fibrous substrate. Rapid membrane freezing with liquid nitrogen (-180 řC) was performed without cryoprotectants to avoid affecting membrane permeability, with only preliminary fixation of protein structures with sodium azide. For comparison, membranes were also frozen by conventional slow freezing to -20 řC and declared as "frozen" membranes. Neither "fresh" nor "flash frozen"... Detailed record

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