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Effect of perinatal hypoxia on cardiac tolerance to acute ischaemia in adult male and female rats.
 Netuka, Ivan ; Pirk, Jan (advisor) ; Tošovský, Jan (referee) ; Vojáček, Jan (referee)
Background: The number of adult patients with history of hypoxaemic insult in childhood has increased significantly. Cardiac interventions performed on these individuals in adulthood have become frequent. The evidence of their possibly specific response to ischaemia while undergoing these procedures is scarce and not sufficiently conclusive. Aim: The aims can be summarized as follows: 1. to develop a method of appropriate measurement and assessement of infarct size induced by regional ischaemia on isolated perfused rat heart; 2. to examine the effect of different types of perinatal hypoxia to the tolerance of the adult myocardium to acute ischaemia/reperfusion injury with regard to sex. (...) Conclusions: The results of the present study support the hypothesis that perinatal hypoxia is a primary programming stimulus in the heart that may lead to sex-dependent changes in cardiac tolerance to acute ischaemia in later adult life. This would have important implications for patients who have experienced prolonged hypoxaemia in early life.
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