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Psychopathology of early-onset schizophrenia and its therapy with focus on atypical neuroleptics
Koblic Zedková, Iveta ; Hrdlička, Michal (advisor) ; Bareš, Martin (referee) ; Stárková, Libuše (referee)
OBJECTIVES: The aim of our study was to assess clinical presentation of early-onset schizophrenia spectrum disoders (EO-SSD), the time to first improvement and efficacy associated with selected atypical (AAPs) and typical (TAPs) antipsychotics, as well as two main side effects - weight gain and treatment-emergent extrapyramidal symptoms (EPSs) during the treatment in patients with EO-SSD. METHODS: This was a systematic chart review of all patients receiving routine clinical care in our department, with selected AAPs (risperidone, olanzapine, ziprasidone, quetiapine and clozapine) and TAPs (haloperidol, perphenazine and sulpiride), for schizophrenic psychoses, between 1997 and 2007. During this period, our review identified 173 patients (85 males, 88 females; mean age 15.8±1.6 years); their treatment included 297 treatment trials. Data on premorbid adjustment, prodromal symptoms and psychopathology at admission, as well as comorbidity were evaluated based on the patients' medical records. The time to first improvement could be estimated in 258 treatment trials; of these, 195 (76%) comprised AAPs and 63 (24%) TAPs. The time to first improvement was assessed in agreement with the methodology established for retrospective studies as the number of treatment days prior to the first record of improvement...
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Growth dynamics in selected rabbit breeds
POUSTKA, Milan
The aim of the thesis was performance comparison of selected populations of three breeds of rabbits, the Moravian Blue (Mm), the Viennese Blue (Vm) and the Dutch rabbit (Ho), that is a large, a medium-sized and a small breed. The monitored aspects were the production characteristics (gain weight and carcass yield) and the reproductive characteristics (the average number of kits born, the number of all kits born, the number of live born and stillborn and successfully weaned kits, the rate of successful pregnancies, the milkness of the doe). The population of each of the breeds was monitored in a selected base of 68 litters of the Mm, 65 litters of the Vm and 84 litters of the Ho. The weight gain of rabbits was monitored in regular intervals from birth until the end of fattening, i. e. until 8 months of age in the Mm and the Vm and until 6 months of age in the Ho. The results were compared with the weight gain required by the breed standard. Based on the observed weight gain, a growth curve has been created using the Richards function in Excel and Statistica 12.0. The monthly weight gain of the monitored breeds was compared. The highest average gain in weight for the Mm was 693 g, for the Ho 480g and for the Vm 539 g. The results show a significantly higher gain in weight throughout the growth period of the Dutch rabbit than is required by the breed standard. The Moravian Blue showed a lower average increase in weight during the first five months of age than is required by the breed standard. High statistical dependence (R = 0,94, p < 0.01) between weight gain and the number of kits per litter was observed during the first month. From the second month dependence get lower. Since the third month of age, this dependence could not be proven. Based on the parameters of the growth curve, the inflection point of growth was established at 59.8 days and weight 1 528 g for the Mm, at 43.2 days and weight 895 g for the Ho and at 67.7 days and weight 1512 g for the Vm. The average number of kits per litter was 6.3 for the Mm, 6.48 for the Ho and 6.23 for the Vm. The milkness was calculated according to the weight of the litter at 2 and 21 days of age. The milkness for the Mm was 3 985 g, for the Ho 2 582 g and 3 176 g for the Ho. A significant statistical dependence (R = 0.97 0.98) between the number of kits in the litter and the milkness was found. The mortality rate was at a low level for all monitored breeds, with the highest (5 per cent) for the Vm , followed by 2.9 per cent forthe Ho and 1.4 per cent forthe Mm. Analysis showed the highest carcass yield for the Dutch rabbit (62.4 per cent), but a lower live weight gain. The carcass yield was 59 per cent for the Vm and only 56.1 per cent for the Mm. Overall, the results of the thesis show a bigger live weight gain in case of the Moravian Blue rabbit provided there are higher demands for housing and feeding. Its progeny shows a greater growth potential and, in some aspects, also better reproductive characteristics. On the other hand, the Dutch rabbit paradoxically reached a higher number of kits per litter and better carcass yield, giving meat of greater quality. The Viennese Blue rabbit had a slightly higher mortality rate than the other breeds but also a relatively large weight gain and carcass yield approaching other medium-sized meat breeds. The results of the thesis can be beneficial for novice breeders in helping them choose the right breed, as well as for existing breeders in helping them improve the strengths and eliminate the weaknesses of these breeds.
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The comparison of fattening results of two beef breed bulls
VEITHOVÁ, Michaela
The aim of this bachelor thesis was to compare the growth ability of two beef breeds, namely Aberdeen Angus and Simmental. Monitoring was carried out on Pěčín Angus Farm led by Mr. Lepš, and data was obtained from 30 bulls, of which 17 were Aberdeen Angus and 13 were Simmental. During the first grazing season bulls were at pasture with their mothers, in winter they were housed in wintering, and from April they were at pasture again. Data for the period of two years was collected. The slaughter weight and age, average daily gain and net gain of bulls were detected. Bulls were classified by the year of birth and breed. Within the breed, the year of birth, the meatiness grade and fat cover classification grade (according to SEUROP classification system) were used as other selection criteria. The dates were processed in Microsoft Excel and Statsoft Statistica. In order to evaluate selected factors, basic statistical values were calculated (the number, the mean, the maximum and minimum, the standard deviation), statistical differences were calculated by t-test and F-test. The average weight of bulls born in 2011 was 744.6 kg and was reached at the age of 638 days. The average daily gain of these bulls was 1109.9 g. The average slaughter weight of bulls born in 2012 was lower (713.8 kg) and was reached later (691 days). The average daily gain of these bulls was 987.8 g. The difference in the average daily gain was statistically significant (P 0.01). Slaughter weight 733.3 kg at the age of 688 days and average daily gain of 1019.8 g was observed within group of Aberdeen Angus bulls. The slaughter weight 721.5 kg at the average slaughter age of 637 days was determined within group of Simmental bulls. Their average daily gain was 1077.8 g. The difference between breeds was statistically significant only in the slaughter age whereas Aberdeen Angus bulls were slaughtered 51 days later (688 vs 637 days, P 0.05). Aberdeen Angus bulls were classified as the "U" meatiness grade with an average slaughter weight of 753.0 kg. The bulls of the "R" meatiness grade had lower slaughter weight (703 kg). Simmental bulls of the "U" meatiness grade reached slaughter weight of 731.6 kg, whereas bulls included into the "R" meatiness grade had an average slaughter weight of 709.7 kg.
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Evaluate the influence of Bio-algeen on selected indicators in the artificial breeding of the Common Pheasant.
SAVULA, Petr
The aim of the work was to evaluate the influence of Bio-algeen on selected indicators in the artificial breeding of the Common Pheasant. These selected indicators were mortality and weight gain of the Pheasants. The research has been conducted in the pheasantry Černiš by České Budějovice on selected flocks of the Common Pheasant. The products that have been used in the experiment were Biopolym FZT and Biopolym Granulate. Biopolym FZT was injected into water in feeding pumps and Biopolym Granulate was added to feeding mixtures. Both products have been added to food every day. It has been found out by the experiment itself that both used products have an effect on the weight gain of the Common Pheasant, but they have no impact on mortality.
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