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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Impaired cognitive coordination on a rotating arena after systemic dizocilpine (MK-801).
 Buchtová, Helena ; Kubík, Štěpán (advisor) ; Olexová, Lucia (referee)
Disruption of cognitive abilities such as learning, memory and spatial navigation accompanies a number of neuropsychiatric disorders including schizophrenia. Cognitive symptoms are also most difficult to target by available pharmacotherapy.. Behavioral and molecular evidence point to a disruption of NMDA receptors and glutamatergic and dopaminergic neurotransmission. Impaired cognitive coordination has been proposed as a core cognitive deficit in schizophrenia. Non- competitive NMDAR antagonists are used to model schizophrenia- related symptoms in humans and in experimental animals. Place avoidance on a rotating arena is used to model cognitive functions disrupted in an animal model of schizophrenia. The goal of this thesis is to show whether the deficit in place avoidance is due to disrupted cognitive coordination or another effect of NMDAR antagonism such as hyperlocomotion, general learning deficit, or altered sensitivity.
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Using the Carousel Maze as a test of cognitive symptoms in an animal model of schizophrenia
 Buchtová, Helena ; Landová, Eva (advisor) ; Jiruška, Přemysl (referee)
Spatial behaviour of animals is used to model cognitive human abilities such as declarative learning and memory. Cognitive deficits accompany a number of neuropsychiatric disorders and their treatment is most problematic. Schizophreniais one of these disorders. Behavioral, neurochamical, and molecular evidence point to a critical role of the NMDA glutamatergic receptors in the pathogenesis of schizophrenia. Disruption of their function results in behavioral and physiological changes including dysregulation of the depaminergic neurotransmission. This fact is used to model schizophrenia-related symptoms by systemic administration of NMDA receptor antagonists. Models combining administration of these drugs with behavioral tests aimed at specific cognitive deficits are of particular interest. This thesis use existing evidence to show that the Carousel Maze is such a behavioral test, which uses dynamic spatial learning to test the ability to coordinate discordant information and specific use of the relevant cues.
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