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Antiviral vaccination - hepatitis A virus
Rančáková, Hana ; Drda Morávková, Alena (advisor) ; Fraiberk, Martin (referee)
Hepatitis A is an ifectious disease caused by Hepatitis A virus (HAV) from Picornaviridae family. HAV is an uneveloped virus composed of positive single-stranded RNA and a capsid with icosahedral symmetry. This infection is wide-spread and endemic in many regions of the world. The main way of transmission is throught the fecal-oral route. The possible symptoms, that can appear during the disease are fever, fatigue, muscle-pain, nausea, vomiting and afterward yellowish discoloration of the skin and mucous membranes. On the other hand, the disease can proceed without any symptoms, that is common especially in the childhood. The people can shelter from the disease by aplication of vaccine. At this time there are four inactivated hepatitis A vaccines at the world market. All of the vaccines are highly effective and provide a long-term protection. This work is intent on the infection of hepatitis A virus, the possibilities of prevention with vaccines and the inclusion of curriculum about viral diseases and vaccination in the School Educational Programmes.
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Antiviral vaccination - hepatitis A virus
Rančáková, Hana ; Fraiberk, Martin (referee) ; Drda Morávková, Alena (advisor)
Hepatitis A is an ifectious disease caused by Hepatitis A virus (HAV) from Picornaviridae family. HAV is an uneveloped virus composed of positive single-stranded RNA and a capsid with icosahedral symmetry. This infection is wide-spread and endemic in many regions of the world. The main way of transmission is throught the fecal-oral route. The possible symptoms, that can appear during the disease are fever, fatigue, muscle-pain, nausea, vomiting and afterward yellowish discoloration of the skin and mucous membranes. On the other hand, the disease can proceed without any symptoms, that is common especially in the childhood. The people can shelter from the disease by aplication of vaccine. At this time there are four inactivated hepatitis A vaccines at the world market. All of the vaccines are highly effective and provide a long-term protection. This work is intent on the infection of hepatitis A virus, the possibilities of prevention with vaccines and the inclusion of curriculum about viral diseases and vaccination in the School Educational Programmes.
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