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Lifestyle, diet and hardening and viral diseases
ČÍŽKOVÁ, Aneta
These topics will be more detailed discussed in the theoretical part, due to their importance in the lives of each of us. Among main topics, the work includes topics related to sleep, rational nutrition, exercise and more within factors that play a significant role in influencing people's health and their lives. In the practical part, the work already deals with cases from practice - everyday life of people. In this section, reader will learn how young people perceive the view of health and its support, and whether they themselves follow the principles of a healthy lifestyle and rational, healthy eating. As a part of the research, respondent's food menus are specifically analyzed, as well as frequency questionnaires mapping the people's diet, the lifestyle and the occurrence of diseases of these people. This work shows and compares the differences in lifestyle within the two investigated groups - people who are hardening and those who are not hardening. The detected shortcomings are discussed in more detail and there are also possible individual recommendations for individuals or the whole group that can be transferred to the wider public. These recommendations are in accordance with the recommendations of the World Health Organization, medicine, or other experts in the field.
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Examination of polymorphisms in the IFITM3 gene using sequences and their clinical significance for the course of viral diseases.
TROJÁKOVÁ, Simona
Interferon Induced Transmembrane Protein 3 is an anti-inflammatory cytokine that belongs to the group of interferon-stimulated genes. The topology of the IFITM3 gene was clarified by the analysis of electron paramagnetic and nuclear magnetic resonance. The protein encoded by this gene induces immunity against influenza A virus and other viral diseases. It also disturbs the homeostasis of intracelular cholesterol, inhibits the entry of viruses into the cytoplasm of the host cells and inactivates new enveloped viruses originating from an infected cell. IFITM proteins reduce virus replication by regulating the expression of viral protein and by reducing the infectivity of developing viruses. The analysis of the single-nucleotid polymorphisms in the IFITM3 gene is very significant to clarify the mechanism of the effect of the IFITM3 protein and its influence on the severity of the course of the viral diseases. The theoretical part deals with the description of Interferon Induced Transmembrane Proteins, particularly the description and function of the IFITM3 gene, including its polymorphisms. This gene is located on chromosome 11 and its size is approximately 18 Kb. The gene variability of the IFITM3 can fundamentally affect the course of influenza and other viral diseases. The practical part of the thesis focuses on the detection of polymorphisms rs12252, rs34481144 and rs1136853 in the IFITM3 gene using the PCR method and Sanger sequencing method. It was necessary to master some basic laboratory methods such as DNA isolation from primary samples, PCR method, preparation of the PCR product for sequencing, sequencing data analysis, processing of results and determination of specific genotypes in tested individuals.
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Parents' attitude to prevention of viral diseases in children
Šašková, Michaela ; Eislerová, Iva (advisor) ; Hrdličková, Renáta (referee)
Key words: parents, children, viral diseases, prevention, attitude Besides introduction and discussion and conclusion, the thesis consists of 3 chapters of theoretic part and the research part. The first chapter of theoretical part forms the general terms viruses and viral diseases. I have mentioned the biology of viruses and its characteristics. The second part of this chapter deals with the most frequent viral diseases in child age. I have described the ways of infection, diseases manifestation, possible complications and shortly the therapy too. The second chapter focuses on the immunity system of children. I have explained this issue generally at first, then I have described the function of immunity and later I have mentioned the development of immunity in children. At the end of the second part there is written about the most important factor of the future quality of immunity in children: the breast milk and breast-feeding. The third chapter deals with the most important topic of my thesis: prevention of viral diseases in children. Firstly I have described a term prevention in general. Then I have focused on the individual ways of prevention. At first I have mentioned the vaccination and then the other ways of prevention. In the research part of the thesis I have focused on my own research. I...
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