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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Functional Annotation of Nucleotide Polymorphism Using Evolution Strategy
 Šalanda, Ondřej ; Martínek, Tomáš (referee) ; Bendl, Jaroslav (advisor)
This thesis brings a new approach to the prediction of the the effect of amino acid substitution. The main goal is to create a new meta-tool, which combines evaluations of eight already implemented prediction tools. The use of weighted consensus over those tools should lead to better accuracy and versatility of prediction. The novelty of developed tool lies in involving evolution strategy with experimentally defined parameters as a way to determine the best weight distribution. At the end, a complex comparison and evaluation of results is given.
Detailed record
Functional Annotation of Nucleotide Polymorphism Using Evolution Strategy
 Šalanda, Ondřej ; Martínek, Tomáš (referee) ; Bendl, Jaroslav (advisor)
This thesis brings a new approach to the prediction of the the effect of amino acid substitution. The main goal is to create a new meta-tool, which combines evaluations of eight already implemented prediction tools. The use of weighted consensus over those tools should lead to better accuracy and versatility of prediction. The novelty of developed tool lies in involving evolution strategy with experimentally defined parameters as a way to determine the best weight distribution. At the end, a complex comparison and evaluation of results is given.
Detailed record

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