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Software Tools for the Analysis of Cardiac Depolarization in Patients with Heart Failure
Smíšek, Radovan ; Richter, Aleš (referee) ; Nováková, Marie (referee) ; Kolářová, Jana (advisor)
Heart failure is a disease in which the heart cannot adequately supply the body with oxygenated blood. Approximately 2% of people in the developed world have heart failure, which is increasing. Cardiac resynchronization therapy, which involves the implantation of a biventricular pacemaker, is used in patients with ventricular dyssynchrony to suppress or at least reduce the symptoms of heart failure. The problem is that 30–50% of patients do not benefit from performed resynchronization therapy. The correct patient selection and the pacemaker implantation and set-up method influence the success rate. The thesis proposes methodologies and software to facilitate the selection of patients suitable for cardiac resynchronization therapy, select the correct pacing lead placement, and optimize pacemaker settings. The developed software is based on standard parameters used in clinical practice (QRS duration, presence of left bundle branch block, classification of heart rhythm) and, in addition, on the analysis of ultra-high-frequency ECG, which provides more detailed information on cardiac activation than the standard parameters used. The developed software helps patients in 16 hospitals in the Czech Republic and abroad.
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