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Functions of Neuregulin 4
Majerčáková, Eva ; Žurmanová, Jitka (advisor) ; Haasová, Eliška (referee)
This work focuses on reviewing the function of Neuregulin 4 (Nrg4) and its receptor ErbB4 in various biological processes and disease states, including inflammation, cancer, metabolic diseases, and liver diseases. In metabolic diseases such as diabetes, Nrg4 may affect glucose metabolism and lipid homeostasis, but the exact mechanism of action is not yet well understood. Nrg4 and its receptor ErbB4 appear to be key factors in regulating inflammation and promoting cell survival. Moreover, in liver diseases, such as nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, Nrg4 and ErbB4 seems to play a protective role. Overall, these findings highlight complex roles of Nrg4 and ErbB4 in a multitude of biological processes and disease states. Further research is needed to fully understand these relationships and their potential as diagnostic or therapeutic targets.
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Intersexual differences of adiposity markers in contemporary Czech children aged 11 - 15 years
Auxtová, Martina ; Sedlak, Petr (advisor) ; Zamrazilová, Hana (referee)
Thesis is focused on the analysis of intersexual differences in adiposity markers within urban population of Czech children from 11,00 to 15,99 years. This age range encompasses puberty which is one of the critical periods for the possible development of overweight and obesity. The sample PRAHA 2013 consists of 356 girls and 353 boys which were surveyed for basic anthropometric indicators - body height, body weight, BMI, mid- upper arm circumference and the thickness of four skinfolds. Intersexual differences discovered in measured parameters show statistical significance (p<0,01 resp. p<0,001) and it corresponds with the characteristic changes of pubertal development in both of genders. Testing file PRAHA 2013 against reference standards and its comparison with the results of the last Czechoslovak spartakiade in 1985 points to positive secular trend of increasing body height. However increase in weight parametres is still continuing. Probands from the year 2013 reach higher body weight values, BMI and skinfold thickness in comparison with children of the same age in 1985, 1991 resp. 2001. Significant differences were found out in the most of age categories in both of genders. Keywords: adiposity tissue, subcutaneous fat, skinfolds, body fat distribution, sexual dimorphism, obesity, secular trend
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Intersexual differences of adiposity markers in contemporary Czech children aged 11 - 15 years
Auxtová, Martina ; Sedlak, Petr (advisor) ; Zamrazilová, Hana (referee)
Thesis is focused on the analysis of intersexual differences in adiposity markers within urban population of Czech children from 11,00 to 15,99 years. This age range encompasses puberty which is one of the critical periods for the possible development of overweight and obesity. The sample PRAHA 2013 consists of 356 girls and 353 boys which were surveyed for basic anthropometric indicators - body height, body weight, BMI, mid- upper arm circumference and the thickness of four skinfolds. Intersexual differences discovered in measured parameters show statistical significance (p<0,01 resp. p<0,001) and it corresponds with the characteristic changes of pubertal development in both of genders. Testing file PRAHA 2013 against reference standards and its comparison with the results of the last Czechoslovak spartakiade in 1985 points to positive secular trend of increasing body height. However increase in weight parametres is still continuing. Probands from the year 2013 reach higher body weight values, BMI and skinfold thickness in comparison with children of the same age in 1985, 1991 resp. 2001. Significant differences were found out in the most of age categories in both of genders. Keywords: adiposity tissue, subcutaneous fat, skinfolds, body fat distribution, sexual dimorphism, obesity, secular trend
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