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Vasculature models to study thrombolysis
 Schildová, Veronika ; Ambrožová,, Gabriela (referee) ; Víteček, Jan (advisor)
The theoretical part of diploma thesis describes the cardiovascular system and focuses on hemostasis. This is a complex of events which maintain functional blood circulation. Hemostasis includes procoagulant processes responsible for elimination of bleeding as well as anticoagulant processes maintain blood fluidity. If there is an imbalance between procoagulation and anticoagulation, thromboembolic or bleeding diseases will occur. This work is focused on one of the most fatal diseases, ischemic stroke, and its treatment by thrombolytics. These are drugs that accelerate the degradation of the blood clot and the recanalization of the blood vessel. This thesis describes the comparison of the only thrombolytic approved for ischemic stroke – alteplase and its mutant tenecteplase. The experimental part is focused on various types of in vitro models to the study of thrombolysis. These are static model, microplate model, thrombus penetration into fibrin gel and sequestration. Such models are used to compare thrombolytics.
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