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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Vasculature models to study thrombolysis
 Schildová, Veronika ; Ambrožová,, Gabriela (referee) ; Víteček, Jan (advisor)
The theoretical part of diploma thesis describes the cardiovascular system and focuses on hemostasis. This is a complex of events which maintain functional blood circulation. Hemostasis includes procoagulant processes responsible for elimination of bleeding as well as anticoagulant processes maintain blood fluidity. If there is an imbalance between procoagulation and anticoagulation, thromboembolic or bleeding diseases will occur. This work is focused on one of the most fatal diseases, ischemic stroke, and its treatment by thrombolytics. These are drugs that accelerate the degradation of the blood clot and the recanalization of the blood vessel. This thesis describes the comparison of the only thrombolytic approved for ischemic stroke – alteplase and its mutant tenecteplase. The experimental part is focused on various types of in vitro models to the study of thrombolysis. These are static model, microplate model, thrombus penetration into fibrin gel and sequestration. Such models are used to compare thrombolytics.
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Investigative CT algorithms for the early diagnosis of ischemic brain lesions
 VOHNOUTOVÁ, Markéta
Stroke is the second most often cause of death in the Czech Republic after heart attack. It is not to say that older people are afflicted in particular. In the last period of ten years there are more often cases of stroke and ictus for people at the age of 40. The aim of this bachelor work is processing of knowledge acquisition in summary. The main point of this work is to evaluate the asset of new software programmes of multidetector computed tomography during early diagnostic of sudden strokes. In part of Present state there are following terms described in detail. It is etiology, aethiopathogenesis, risk factors of stroke. The next part is centred on anatomy of brain vascular supply and computed tomography Nowadays, software programmes have been improved enough for early diagnostics of ischaemic brain lesion. It is caused with continual improvement of diagnostic imaging and its digitalization. In many medical fields it has been spoken about new field of imaging - digital radiography. The computed tomography represents star part in the diagnostics, scanning of non-enhanced brain is the first period of the diagnostics, this algorithm shows us if it concerns haemorrhage or non-haemorrhage centre, continuing perfusion of brain which represents chat percent of tissue is damaged forever and it is finished with diagnostic process Angiography. The following part is focused on processing of data acquisition from České Budějovice Hospital, Inc. and Masaryk Municipal Hospital in Jilemnice. In these hospitals there are the numbers of patients examined CT compared. My hypotesis is confirmed and I can say that usage of new software programmes for early diagnostic of sudden strokes reduces per cent of complications during their cure.
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