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National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Stimuli - responsive nanoparticles with boronic ester linkages as a potential carrier for drug delivery
 Hlavatovičová, Eva
This thesis deals with the post-polymerization functionalization of a pH-responsive poly(styrene)-b-poly(4-vinyl pyridine)-b-poly(ethylene oxide) triblock terpolymer with stimuli responsive and diol-binding 2-bromomethyl-4-fluorophenylboronic acid and 2- bromomethyl-phenylboronic acid suitable for biomedical applications. A reproducible method of quaternization of poly(4-vinyl pyridine) block with prescriptible quaternization ratio was developed and the reaction yield was analyzed by 11 B, 1 H NMR and infrared spectroscopy. A reproducible self-assembly protocol for stable nanoparticles from functionalized stimuli-responsive triblock terpolymer was found, and the nanoparticles were studied by static, dynamic and electrophoretic light scattering, and cryogenic transmission electron microscopy. Fluorescence and UV-VIS spectroscopy measurements were performed for description of boron-ester linkages formation and hydrolysis with model drug Alizarin as a study of encapsulation and release reactions together with sugar sensing reactions for potential drug delivery.
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Stimuli - responsive nanoparticles with boronic ester linkages as a potential carrier for drug delivery
 Hlavatovičová, Eva ; Uchman, Mariusz Marcin (advisor) ; Strachota, Adam (referee)
This thesis deals with the post-polymerization functionalization of a pH-responsive poly(styrene)-b-poly(4-vinyl pyridine)-b-poly(ethylene oxide) triblock terpolymer with stimuli responsive and diol-binding 2-bromomethyl-4-fluorophenylboronic acid and 2- bromomethyl-phenylboronic acid suitable for biomedical applications. A reproducible method of quaternization of poly(4-vinyl pyridine) block with prescriptible quaternization ratio was developed and the reaction yield was analyzed by 11 B, 1 H NMR and infrared spectroscopy. A reproducible self-assembly protocol for stable nanoparticles from functionalized stimuli-responsive triblock terpolymer was found, and the nanoparticles were studied by static, dynamic and electrophoretic light scattering, and cryogenic transmission electron microscopy. Fluorescence and UV-VIS spectroscopy measurements were performed for description of boron-ester linkages formation and hydrolysis with model drug Alizarin as a study of encapsulation and release reactions together with sugar sensing reactions for potential drug delivery.
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Multicompartment nanoparticles based on ABC triblock terpolymers as potential drug delivery vehicels
 Hlavatovičová, Eva ; Uchman, Mariusz Marcin (advisor) ; Trhlíková, Olga (referee)
This thesis deals with the self-assembly behavior of newly synthetized well-defined amphiphilic poly(acrylic acid)-b-poly(4-hydroxystyrene)-b-poly(styrene-carborane) triblock terpolymer in aqueous solution. A reproducible method was developed for the preparation of diverse multicompartment boron-containing nanostructures (spherical micelles, wormlike micelles) depending on the initial solvent composition and solvophobic-solvophilic interactions. Self-assembled nanostructures were characterized by various techniques (static and dynamic light scattering, cryogenic transmission-electron microscopy and fluorescence spectroscopy). The solubilization of two model drugs (2-methylnaphtalene and 7- methoxycoumarine-carborane fluorophores) in polymer nanoparticles was studied by fluorescence spectroscopy to investigate its potential in drugs solubilization and delivery.
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