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Tracking the progression of Alzheimer's like-pathology in transgenic rat model TgF344-AD
Foltýnová, Alice ; Telenský, Petr (advisor) ; Němec, Pavel (referee)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting dominantly the elderly and it is the most common cause of dementia. AD is characterized by many pathological events such as amyloid plaques, neurofibrillary tangles, inflammation, neurotransmitter dysregulation and many others. These disruptive processes ultimately lead to synaptic and cell loss which human brain. According to literaure, cell loss in AD is apparent especially in the cortex and hippocampus. However, it is unclear at which timepoint the loss becomes significant and in which other structures. There are many other important structures such as olfactory bulbs or entorhinal cortex where the cell loss has not been fully quantified. With new methods like isotropic fractionator it has become possible for scientists to quantify large number of structures more quickly. Since human brains are not easy to obtain shortly after death, use of transgenic animal models, mostly rodents, is a good way to obtain more information about cell and especially neuronal loss occurring in AD. Key words: Alzheimer's disease, cell loss, isotropic fractionator, hippocampus, neurofibrillary tangles, beta amyloid
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