National Repository of Grey Literature 532 records found  previous11 - 20nextend  jump to record: Search took 0.02 seconds. 
Functional and structural study of thermally activated TRP ion channels: The role evolutionarily conserved motifs in the TRPA1 modulation
Kádková, Anna ; Vlachová, Viktorie (advisor) ; Hudeček, Jiří (referee) ; Obšilová, Veronika (referee)
Ankyrin receptor TRPA1 is an ion channel widely expressed on primary afferent sensory neurons, where it acts as a polymodal sensor of nociceptive stimuli. Apart from pungent chemicals (e. g. isothiocyanates, cinnamaldehyde and its derivatives, acrolein, menthol), it could be activated by cold temperatures, depolarizing voltages or intracellular calcium ions. TRPA1 channel is a homotetramer in which each subunit consists of cytoplasmic N and C termini and a transmembrane region. The transmembrane part is organized into six alpha- helices connected by intra- and extracellular loops. The N terminus comprises a tandem set of 16 to 17 ankyrin repeats (AR), while the C terminus has a substantially shorter, dominantly helical structure. In 2015, a partial cryo-EM structure of TRPA1 was resolved; however, the functional roles of the individual regions of the receptor have not yet been fully understood. This doctoral thesis is concerned to elucidate the role of highly conserved sequence and structural motifs within the cytoplasmic termini and the S4-S5 region of TRPA1 in voltage- and chemical sensitivity of the receptor. The probable binding site for calcium ions that are the most important physiological modulators of TRPA1 was described by using homology modeling, molecular-dynamics simulations,...
Changes of physical-chemical parameters of surface water in context with hydrological extremes. Application in the Rolava River catchment.
Šajnarová, Lucie ; Matoušková, Milada (advisor) ; Havlíková, Petra (referee)
6 Abstract The diploma thesis deals with changes in the physico-chemical parameters of surface flows in response to extremes, especially increased flows due to higher precipitation totals or melting snow. The basin of the upper Rolava with peat bogs in the basin and minimal anthropogenic influence was used. The main goal of the work was the analysis of the behavior of electrical conductivity during events when there was an increase in flow rates and the categorization of individual events according to this behavior. Furthermore, the influence of the pre-condition of the watershed on the events and the subsequent behavior of the electrical conductivity was also investigated. The 10-minute electrical conductivity and flow data from the automatic stations of the ecohydrology team of the Faculty of Science, UK, or ČHMÚ were used. Among the methods are data homogenization, construction of hysteresis loops, categorization of loops, calculation of indices for hysteresis loops and PCA analysis for the pre-condition of the watershed. In most cases, a reverse relationship of electrical conductivity behavior was observed during these events, the most common types of electrical conductivity behavior during flow increases include a slow decrease in conductivity with minimum values after the peak of flow (in light...
Impacts of global climate change on lichens
Šubrtová, Tereza ; Malíček, Jiří (advisor) ; Peksa, Ondřej (referee)
Lichens, also known as lichenized fungi, are primarily known as excellent indicators of environmental change. Due to climate change, lichens are increasingly being studied for their indication and prediction of individual factors of global climate change. In the first part of this work, individual abiotic factors affecting lichens on a global scale are examined, to understand these factors in all possible environments. The next part of the work focuses on Europe and addresses the history of the development and future prediction of lichen distribution under the influence of climate change. The end of the work is focused on the territory of the Czech Republic and mentions the most affected species in our area. The study of global climate change on lichens is important not only for understanding the effects of environmental changes on organisms but also for proper prioritization of nature protection leading to a halt in the decline of species and their habitats.
Study of the difference between natural gas and hydrogen combustion
Winter, Josef ; Lisý, Martin (referee) ; Baláš, Marek (advisor)
This thesis deals with the combustion of natural gas with hydrogen in certain volumetric concentrations. The change in physical parameters due to the addition of hydrogen, which differs in its properties from natural gas, was studied. The thesis is divided into a research part, where the properties of natural gas and hydrogen are described, including a comparison with each other, the effects of gas properties on flame, emissions, or temperature. In the second part, a calculation for the fireplace with chosen dimensions was performed and the changes in physical properties due to the addition of hydrogen were observed and the findings are summarized, which will have to be considered in the design of the fireplace. All calculations are added to the appendices.
Coupled model of transformer
Adamec, Lukáš ; Huzlík, Rostislav (referee) ; Vlach, Radek (advisor)
The bachelor's thesis deals with the creation of a coupled model of transformer in the Matlab system. The coupled model connects two basic physical domains - electricity and heat transfer. It all starts with the selection of suitable equivalent circuit diagrams that represent the electrical and thermal properties. Their connection is then called as coupled model, which captures their mutual influence. An important part of the thesis is the identification of elements (thermal resistances and capacities, stray inductance, etc.) of equivalent circuit. Open-circuit and short-circuit tests are used to identify electrical elements, thermal elements are then determined from the temperature curves of the sub-parts of the transformer – core and winding. The goal of the thesis is that the output of the coupled model corresponds as closely as possible to the behavior of a real transformer. Compliance is verified by the final simulation.
Monitoring the living environment in the house
Dlugoš, Daniel ; Ježek, Michal (referee) ; Staněk, Kamil (advisor)
This work, tries to create a small, rechargeable and portable device that senses temperature, humidity, barometric pressure, dust particles, carbon dioxide and VOC concentration. The air quality monitor can reliably measure the physical quantities encountered in every indoor environment, evaluate them and display them to the user. The sensors, data storage module and OLED display are housed on a custom-made PCB board.
The influence of cold RAP addition on the resulting temperature of the asphalt mixture
Bocák, Tomáš ; Hýzl, Petr (referee) ; Dašek, Ondřej (advisor)
The aim of the bachelor thesis is to simulate the effect of dosing cold reclaimed asphalt into a hot aggregate mixture, under laboratory conditions. The theoretical part will describe the possibilities of reclaimed asphalt dosing in the production of asphalt mix, together with the principles for the design of a new asphalt mix. In the practical part, by my proposed procedure, the cold portion of aggregate will be mixed with the hot portion of aggregate. The measurements will result in the final aggregate mixture temperatures and their comparison.
Electronic temperature measurement for a grill
Svoboda, David ; Burian, František (referee) ; Fiedler, Petr (advisor)
The work deals with methods of temperature measurement, electrical and non-electrical. Discussing the advantages and disadvantages of electrical methods of temperature measurement for applicability in the grill. It also discusses the selection of a suitable sensor to measure the temperature inside the grill. Subsequent design and implementation of the measuring system where the emphasis is on accuracy.
Design of the on-board system for a motorcycle
Ševčík, Jan ; Benešl, Lukáš (referee) ; Juráň, Radovan (advisor)
This work deals with the design and construction of an on-board computer for a vintage Jawa motorcycle. The design combines measuring sensors of our own design and those commonly available on the market, a main control board of our own design and assembly without interfering with the structure of the motorcycle. The system is considered for mounting on the Jawa 250/592 motorcycle, with some parts from other motorcycles, allowing for easier fitting. ESP32 from Espresiff is used as a microcontroller, which is placed in the tank of the motorcycle and displays the measured data on the LCD display. The system also allows you to control the entire motorcycle, such as enabling starting or turning on the lights
Experimental equipment for testing of temerature influence on permanent magnet parameters
Ouroda, Jan ; Diakov, Jakub (referee) ; Vlach, Radek (advisor)
This thesis presents the design and manufacturing of an experimental device for measuring permanent magnet´s pull force and it´s dependency on temperature. The introductory part includes an introduction to permanent magnet brushless motors, properties of permanent magnets and methods for testing of said properties. Main part of the thesis focuses on the design and manufacturing of the mechanical structure, electronics, and software of the device.

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