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Optical characterization of supramolecular complexes of selected organic fluorophores with cyclodextrins
Haiklová, Simona ; Dian, Juraj (advisor) ; Červený, Václav (referee)
The content of this thesis is the optical characterization and determination of the strength of supramolecular interaction of selected organic fluorophores and cyclodextrins (CD) using the stability constant with optical methods: UV-Vis absorption and fluorescence. Two series of fluorophores differed in the presence of groups with two positive charges, and two types of cyclodextrins (-CD a -CD) with different cavity sizes were chosen for the study. Fluorophores with charged end groups can be efficiently bound by electrostatic interaction on solid surfaces of suitable chemical composition or thin films with an excess of negative charge and thus immobilized by a very strong interaction on a given support. These prepared surfaces or layers can then be used for the optical detection of chemical substances. The aim of this work was to determine the influence of cyclodextrin cavity size, the presence of a charged anchor, and solution pH on the supramolecular interaction of the studied systems and evaluate the application possibilities of the studied systems for optical chemosensors. In the presented thesis, the change in optical absorption and fluorescence intensity of four pairs of fluorophores: PRODAN, RhB, RhB-Si, DANSA, and their derivatives with a charged anchor was studied during supramolecular...
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Studium teplotně citlivých porfyrinů a jejich supramolekulárních komplexů
Hrubovský, Martin ; Kouřilová, Hana (advisor) ; Srb, Pavel (referee)
Study of thermoresponsive porphyrins and their supramolecular complexes Abstract: We studied the water-soluble artificial compound meso-tetrakis{3,4,5-tris[2-(2-(2- methoxyethoxy)ethoxy)ethoxy]phenyl}porphyrin prepared at NIMS, Japan, using the high-resolution NMR spectroscopy experimental method. We observed its LCST-type phase separation and applied the Flory-Huggins theory of polymer solutions in order to find its phase diagram (binodal and spinodal curves of the phase separation) and we also obtained molar enthalpies, entropies and critical temperatures of its phase separation; from the Flory-Huggins theory we discovered that its molecules form dimers in aqueous solutions. We also studied its host-guest interactions with the S-camphorsulfonic acid; we learned that the porphyrin binds cations and the porphyrin dimers break down when dissolved cations are available for complexation. We observed no phase separation in chloroform. We obtained no proof of the existence of molecular stacks larger than dimers. 1
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