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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Application of special methods in diagnostics of benign and malignant mucosal lesions of upper aerodigestive tract.
 Zábrodský, Michal ; Bouček, Jan (advisor) ; Čelakovský, Petr (referee) ; Šlapák, Ivo (referee)
Optical imaging methods incorporating observation of the mucosal surface of organs with narrowband filtered light are diagnostic tools with a significant development in recent years and have become an integral and inseparable part of the diagnostic process of benign and malignant pathologies of the mucosal surface of various anatomical systems of the human body. Malignant and premalignant lesions of the upper aero-digestive tract (UADT) are no exception. The present work demonstrates the benefits of evaluation of changes in microvascular architecture by narrowband imaging. Its major advantage is a more accurate diagnosis of premalignant and malignant mucosal pathologies in the head and neck region based on the identification of significant changes in superficial vascularity. There is a very strong correlation of these vascular changes with the final histopathological analysis. The present data have shown that videoendoscopic examination with narrowband imaging significantly improves the distinction between benign and malignant mucosal lesions even in the UADT pathologies with a similar tendency to neoangiogenesis (squamous cell papilloma vs. squamous cell carcinoma). It also refines the determination of surface extension of tumoral changes and helps to localize and accurately diagnose tumors of...
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Radiation therapy of non-melanoma-type skin tumors
 MENCLOVÁ, Lucie
Skin tumors of non-melanoma type (particularly basal cell cancer and squamous cell cancer) include a large and important group of malignant lesions. Their incidence in human population has been steadily increasing. The current treatment modalities include surgical excision and radiation therapy. The advantages of radiation include the ease of application, pain-free administration and excellent cosmetic result. The goal of radiotherapy is a homogeneous dose distribution in the entire volume of target tissue. This distribution is affected by a choice of particular radiation criteria, which are individually selected for each patient undergoing radiation. The choice of a particular technique of radiation is affected by a number of factors such as microscopic findings, tumor localization, TNM classification, etc. Analysis of data collected in a group of patients treated by radiation at the Department of Radiation Therapy and Oncology FNKV during the period from 2001 to 2006 showed, that there has been a steady rise in incidence of these non-melanoma skin tumors. This confirms the importance of this topic.
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