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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
The role of tyrosine phosphorylation in hnRNA splicing
 Koudelková, Lenka ; Brábek, Jan (advisor) ; Kozáková, Eva (referee)
Coding sequences of eukaryotic genes are interrupted by long segments of noncoding intronic DNA, which must be spliced after a transcription into a heterogenous nuclear RNA. Due to an increasing pressure on complexity of proteome eukaryotic organisms evolved alternative splicing. It is enabled through weak consensus sequences of splice sites flanked with accessory regulatory RNA elements, that associate with splicing factors, to create protein products according to current requirements implicated by outer and inner conditions. The net of cooperatively or antagonistic acting factors determines whether splice sites are recognized or not. This molecular system is regulated by enzymatic modifications depending on activity of corresponding signaling pathways. Beside many other enzymes a family of protein tyrosine kinases is involved in the process. Via catalytic activity of their kinase domains, they add phosphate to tyrosines of proteins that participate in RNA metabolism. Phosphorylation affects their affinity for RNA and other interacting partners, localization, enzymatic activity or other properties. The changes result in establishing of new setting of regulatory net and usage of distinct splice sites. Products then may with a different efficiency inhibit or trigger various cell processes or...
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