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Antidepressant sertraline and fish behavior
LEXOVÁ, Veronika
Consumption of antidepressants, including sertraline, increases annually. After their intake and excretion, the residues of pharmaceuticals and their metabolites enter recipients with insufficiently treated wastewater, and they can negatively affect non-targeted organisms. This diploma thesis deals with the occurrence of antidepressant sertraline in the aquatic environment, its bioaccumulation and its effect on fish behaviour. In the experimental part of this thesis, brown trout were exposed to an environmental concentration of sertraline of 100 ng/l. Afterwards, their behaviour was observed. Results suggest that sertraline caused a change in spatial orientation expressed with left-sided laterality. Also, exploration activity was changed, which was higher in exposed fish than in the control group. It means that exposed fish were exploring the whole labyrinth. The Fulton condition factor also affected the exploratory activity of the fish. Fish in lower conditions were more likely to explore the entire tank. Concentrations of sertraline and its active metabolite norsertraline were detected in the brain and liver of fish using liquid chromatography with mass spectrometry. According to the calculation of the bioconcentration factor, it is possible to say that sertraline in trout does not reach the value of the bioconcentration factor, where substances are considered to be highly bioaccumulative. Furthermore, results suggest that the concentration of both substances in fish brains affected fish behaviour, specifically their left-sided laterality and higher exploration activity. As the concentration in the fish brain increased, the probability of these changes was higher.
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Kdo je boss teď? aneb dopad farmaka sertralinu na hierarchii raků
MAREŠ, Josef
Pharmaceuticals' pollution of open waters is a current threat to aquatic organisms. The development of pharmacies and increased consumption of drugs leads to a burden on the aquatic environment with dangerous pollutants. Due to the fast and stressful lifestyle, the consumption of antidepressants increases significantly in the majority of the human population. After consumption and excretion, antidepressants and other drugs enter groundwater and surface water through wastewater treatment plants, which can have a secondary effect on non-target organisms. This master thesis assesses the possible impact of the commonly used antidepressant sertraline on the mutual social behavior of marbled crayfish (Procambarus virginalis). The experiment was based on monitoring the behavior of different pairs of different crayfish. The created dyads assessed mutual interactions between control crayfish, crayfish exposed to sertraline, and reciprocally between both crayfish groups. Three weeks before monitoring, crayfish were exposed to an environmentally relevant sertraline concentration of 1 g?l-1. The results were evaluated by sensory assessment according to available methods, and subsequently, the statistics were assessed. No group of crayfish observed showed a significant difference in behavior. Thanks to the initial phase of experiments of this type, we cannot determine with certainty from the results that sertraline does not affect the social behavior of marbled crayfish. However, along with other antidepressants, sertraline, a selective serotonin reuptake inhibitor, is undoubtedly a potential threat to the environment.
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