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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
SMV-2015-37: Development of an animal model of septic encephalopathy for MR studies, execution and evaluation of a pilot study
 Starčuk jr., Zenon
Two animal models of septic encephalopathy in mice were tested: the induction by lipopolysaccharide, and the fecal model, whose objective was to test their applicability in the study of pathophysiology of septic encephalopathy by magnetic resonance in 9.4 Tesla field. Three MR imaging protocols were optimized: T2-weighted RARE for morphological imaging, protocols for native perfusion imaging ASL, and for contrast-enhanced perfusion imaging DCE applying Magnevist, whose main target was the detection of potential changes in the cerebral blood flow and alteration of the blood brain barrier function. Measurements were performed in Bruker Biospec 94/30 with a set of 27 mice anesthesized by isoflurane, whose physiological functions were continuously monitored. The original and analyzed data were provided to the client.
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