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Analysis of drug residues in waters from small wastewater treatment plants
Pešková, Karolína ; Repková, Martina (referee) ; Mravcová, Ludmila (advisor)
This diploma thesis is focused on the analysis of pharmaceuticals residues in wastewater from wastewater treatment plants used for smaller sources of pollution (up to 2000 population equivalent). Pharmaceuticals entering the environment are a highly discussed topic, especially due to the emergence of antibiotic resistance, negative effects on non-target organisms, vegetation etc. The theoretical part of the thesis deals with smaller wastewater treatment plants or root sewage treatment plants, which achieve excellent results in the field of organic pollution removal. It deals with their detailed description, functioning or division. Attention is paid to pharmaceuticals in general, mechanisms of their removal and methods of their determination in wastewater. In total of 24 drugs from the group of beta-blockers, macrolide antibiotics, non-steroidal anti-inflammatory drugs, antiepileptics, antidepressants and sulfonamides were selected for analysis. In the experimental part of this diploma thesis, wastewater samples were taken from domestic wastewater treatment plants (type AT 6, AT 12 Plus, AT 30 and AT 150) and from the root sewage treatment plant of Dražovice. The samples were first processed using optimized extraction method (solid phase extraction) and then analyzed using optimized UPLC-ESI-MS method. The presence of pharmaceuticals residues was confirmed in all analysed wastewater. The highest concentrations were detected for the non-steroidal anti-inflammatory pharmaceuticals – ibuprofen and diclofenac.
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Analysis of drug residues in waters from small wastewater treatment plants
Pešková, Karolína ; Repková, Martina (referee) ; Mravcová, Ludmila (advisor)
This diploma thesis is focused on the analysis of pharmaceuticals residues in wastewater from wastewater treatment plants used for smaller sources of pollution (up to 2000 population equivalent). Pharmaceuticals entering the environment are a highly discussed topic, especially due to the emergence of antibiotic resistance, negative effects on non-target organisms, vegetation etc. The theoretical part of the thesis deals with smaller wastewater treatment plants or root sewage treatment plants, which achieve excellent results in the field of organic pollution removal. It deals with their detailed description, functioning or division. Attention is paid to pharmaceuticals in general, mechanisms of their removal and methods of their determination in wastewater. In total of 24 drugs from the group of beta-blockers, macrolide antibiotics, non-steroidal anti-inflammatory drugs, antiepileptics, antidepressants and sulfonamides were selected for analysis. In the experimental part of this diploma thesis, wastewater samples were taken from domestic wastewater treatment plants (type AT 6, AT 12 Plus, AT 30 and AT 150) and from the root sewage treatment plant of Dražovice. The samples were first processed using optimized extraction method (solid phase extraction) and then analyzed using optimized UPLC-ESI-MS method. The presence of pharmaceuticals residues was confirmed in all analysed wastewater. The highest concentrations were detected for the non-steroidal anti-inflammatory pharmaceuticals – ibuprofen and diclofenac.
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