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Hybrid gellan hydrogels
Borovský, Martin ; Přibyl, Jiří (referee) ; Krouská, Jitka (advisor)
The subject of this bachelor thesis was the preparation of hybrid gellan hydrogels based on the combination of physical crosslinking and ionic interaction of the functional groups of gellan with multivalent ions of selected metals. These materials were subsequently characterized by analysis on their mechanical properties, ability to swell in aquatic environment, and by studying of their rate of drying using drying scales. The results of the study indicate that hybrid crosslinked hydrogel networks provide better mechanical properties, thus these hydrogels have high application potential. From the obtained data it was found that hydrogels with the addition of multivalent ions exhibit a higher degree of crosslinking of their hydrogel network, which positively affects the resulting properties of the hydrogels. By using different types of ions at variable concentrations, the hydrogels with a wide range of properties can be prepared. In conclusion, the experimental findings are summarized and an overview of the influence of multivalent ions on the mechanical properties of hydrogels is provided.
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Rheological study of high-molecular weight hyaluronan-protonated aminoacids interactions
Zeman, Jan ; Běťák, Jiří (referee) ; Chytil, Martin (advisor)
The study deals with interactions of hyaluronic acid with protonized amino acids Lysin and 6-aminocaproic acid. To study the interactions pH-metry, conductance measurement and reometry were used. The mixtures of hyaluronan and the aminoacids of different concentrations were measured and the data were compered with data obtained from measurement of amino acid samples in pure water. Observed interactions occured in the aminoacids concentrations between 0 to 10 mmolxdm3, then the HyA carboxylic groups were fully bonded by amino acids and no more interactions were recognized.
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Rheological study of high-molecular weight hyaluronan-protonated aminoacids interactions
Zeman, Jan ; Běťák, Jiří (referee) ; Chytil, Martin (advisor)
The study deals with interactions of hyaluronic acid with protonized amino acids Lysin and 6-aminocaproic acid. To study the interactions pH-metry, conductance measurement and reometry were used. The mixtures of hyaluronan and the aminoacids of different concentrations were measured and the data were compered with data obtained from measurement of amino acid samples in pure water. Observed interactions occured in the aminoacids concentrations between 0 to 10 mmolxdm3, then the HyA carboxylic groups were fully bonded by amino acids and no more interactions were recognized.
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