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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Role of Renal functional reserve (RFR) in developing and recovering from cisplatin-induced renal injury
 Hromadová, Pavlína ; Pávek, Petr (advisor) ; Trejtnar, František (referee)
University in Salamanca Faculty of Pharmacy Toxicology Area, Department of physiology and pharmacology Candidate: Pavlína Hromadová Supervisor: Prof. Rosa Laura Vicente, Ph.D. Prof. PharmDr. Petr Pávek, Ph.D. Title of diploma thesis: Role of RFR in developing and recovering from cisplatin-induced renal injury The purpose of this study was to find out the role of renal functional reserve (RFR) during development and recovery from cisplatin renal damage. This work focuses on evaluating whether RFR can detect (stages) of kidney damage that are not diagnosed with the clinical reference biomarker: plasma creatinine. To evaluate the RFR, Wistar rats produced in the animal house of the University of Salamanca were used. A protocol was established in which an intravenous perfusion of the amino acid glycine was used as a stressor and the glomerular filtration rate was evaluated through creatinine clearance. The animals received a toxic dose of cisplatin and the RFR was determined in one group two days before the maximum point of toxicity (day 2 of the experiment, evolution of kidney damage), in another one on the day of maximum toxicity (day 4) and in the last group on day 11 (recovery from kidney damage) after drug administration on day 0. The values are compared with those of a control group not treated...
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The role of endothelin system in the treatment of chronic renal failure
 Drábková, Natálie ; Vaněčková, Ivana (advisor) ; Vebr, Pavel (referee)
Chronic kidney disease (CKD) is a life-threatening disease arising as a frequent consequence of diabetes and hypertension. Since it is silent for a long time, it often progresses to end-stage renal disease (ESRD). Managing chronic kidney disease, the prevalence of which is sharply increasing in the last decades due to the ageing of the world population, is thus major health problem. Apart from blockers of renin-angiotensin system, which are used as the "golden standard" in the treatment of CKD due to their antihypertensive and renoprotective effects, other strategies are also applied for the management of this disease. A relatively new class of therapeutics - blockers of endothelin system - seems to be very promising in this field.
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