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National Repository of Grey Literature

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Prediction of the effect of mutations on protein stability Rosinská, Monika ; Martínek, Tomáš (referee) ; Musil, Miloš (advisor) Cílem této práce bylo vytvořit klasifikační model, který dokáže rozlišovat mutace proteinu jako stabilizující či destabilizující. Model byl implementován pomocí konvolučních neuronových sítí s využitím předtrénované sítě ResNet50V2 a datové sady založené na FireProtDB. Model dokáže predikovat vliv mutací na stabilitu proteinu s přesností 0.7 a zároveň poskytuje informaci o míře jistoty dané predikce. Detailed record

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