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Neuropsychological differential diagnosis of selected movement disorders
Tegelová, Vendula
Title: Neuropsychological Differential Diagnosis of selected Movement Disorders Author: Bc. et Bc. Vendula Tegelová Supervisor: Mgr. et Mgr. Tomáš Nikolai, Ph.D. Number of pages and characters: 106; 198 530 Number of appendices: 1 Number of references: 206 Abstract: The diploma thesis deals with the insight into the problems of the extrapyramidal system and its diseases and the key structures of the extrapyramidal system - basal ganglia. Furthermore, a basic description of Parkinson's disease (PN), progressive supranular palsy (PSP) and multisystem atrophy (MSA) with emphasis on the cognitive aspects of these diseases. Thesis also deals with neuropsychological examination in clinical practice, in more detail screening methods of cognitive functions, which are a necessary part of the diagnosis of cognitive deficits. We briefly describe selected screening methods, including the Mattis dementia scale (DRS2), which is used in the empirical part of the work. The theoretical part concludes with a brief search of studies that examine using DRS2, but also other screening methods, cognitive deficit and cognitive profile, especially in PN, PSP and MSA, but also in other neurodegenerative diseases. The empirical part of the work focuses on the analysis of DRS2 results in patients with PN, PSP and MSA, taking...
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Clinical variability of rare dementias: manifestations and possible reasons
Tesař, Adam ; Rusina, Robert (advisor) ; Baláž, Marek (referee) ; Hort, Jakub (referee)
Clinical variants of dementia are limiting their diagnosis and can leads to underdiagnosing or substitution of two different diseases with the same symptomatology. The aim of this study is a better understanding of a factors involved in the clinical variability of rare dementias. Progressive supranuclear palsy and Gerstmann-Sträussler-Scheinker syndrome caused by mismatch mutation P102L in Prion protein are used as model diseases. In this thesis, we firstly demonstrate the influence of the distribution of neuropathology and its spread on the clinical phenotype of the disease. Although a single neurodegenerative disease increases the risk of neurodegenerative comorbidity, this other neuropathology does not affect the phenotypic presentation of the primary disease. Monogenetically inherited proteinopathies can have a different clinical subtype, which is not only conditioned by causal protein polymorphisms, but can be influenced by the wild type allele of causal protein. A more accurate understanding of the symptomatic variability in dementias will allow a better focus of a drug studies and, in the future a treatment, but it will also lead to a better understanding of the pathogenesis of neurodegenerative diseases. Keywords: dementia, Progressive supranuclear palsy, Gerstmann-Sträussler-Scheinker...
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