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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Software using random forest for risk prediction of heart valve surgery patients
 HERMANUTZ, Georg
CASPeR - Cardiac surgery prediction tool for risk stratification of heart valve surgeries is presented. The base builds a machine learning pipeline for training a random forest classifier which predicts the mortality after a certain amount of days after the surgery was performed. The classifier also offers a list of potential risk factors through its in build feature selection. With a survival analysis the groups "high-risk" and "low-risk" are compared with each other to check for statistical difference. The tool uses "Shiny" a R package which offers a web frame work to develop data analysis visualizations for the User Interface. CASpeR is delivered as a Microsoft Windows standalone desktop application, that comes with a .exe installer and a detailed manual.
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Ethical issues of the predictive genetic diagnosis
 ČAPKOVÁ, Jitka
This bachelor's thesis deals with ethical issues of the predictive genetic diagnosis. The goal of this thesis is to introduce ethical issues of the predictive genetic testing that is developing rapidly, and present possible questionable aspects that our society will have to deal with. This thesis is based on a hypothesis that the predictive testing must take place only within specialized genetic departments, on the basis of observing basic ethical and legal principles, to minimize moral dilemmas and maintain dignity of the human existence. The theoretic part focuses on introducing the issues of genetic testing. This thesis puts emphasis especially on ethical reflection of genetic testing issues such as genetic discrimination, genetic testing of children, and interpretation of the results of predictive genetic testing. Definition of the principle of human dignity as a moral basis of the predictive medicine, and analysis of selected documents, agreements, and programmes relating to human dignity and rights related to the field of genetic testing will be also included.
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