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A case study of physiotherapeutic treatment of a patient after acute respiratory failure due to pneumonia combined with pulmonary oedema
Zdobinská, Nela ; Dvořáčková, Dominika (advisor) ; Sárazová, Daniela (referee)
Title: A case study of physiotherapeutic treatment of a patient after acute respiratory failure due to pneumonia combined with pulmonary oedema. Objectives: The aim of this bachelor thesis is to introduce the problematics of respiratory diseases including anatomical context, the possibilities of treatment and rehabilitation based on EBM. The practical part concerns case report of the patient diagnosed with acute respiratory failure due to pneumonia combined with pulmonary oedema. Methods: The bachelor thesis is divided into two parts - theoretical and practical. The theoretical part consists of anatomy, physiology, and pathophysiology of the respiratory system, introduction to the problem of acute respiratory failure, pneumonia and pulmonary oedema, as well as the most commonly used physiotherapeutic methods used to treat patients with this condition. The practical part is a case study of a patient after acute respiratory failure due to pneumonia combined with pulmonary oedema. The elaboration of the case study was made during continuous professional practice in Institute for Clinical and Experimental Medicine in Prague, in the period from 10 January 2022 to 4 February 2022 under the expert guidance of Mgr. Daniela Sárazová and Bc. Robert Charvát. The bachelor thesis includes kinesiological...
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Mechanisms involved in sodium uptake activation by the Tumor Necrosis Factor-derived TIP peptide
DULEBO, Alexander
The Tumor Necrosis Factor derived-TIP peptide is a small 17 amino acids cyclic peptide with lectin-like activity, that possesses several therapeutically relevant biological activities, among which is activation of alveolar liquid clearance in both healthy and injured lungs in vivo. Accumulation of fluid in the lungs? alveoli and interstitial spaces is a life-threatening condition called pulmonary edema. The mortality rate due permeability pulmonary edema, accompanied by a dysfunction of the alveolar/capillary barrier, is high because no effective treatment lacking side effects exists nowadays. It is known that the TIP peptide is able to activate vectorial Na+ transport ? which mediates lung liquid clearance. However, the mechanism of action of remains elusive. The aim of this thesis was to investigate the initial steps of interaction between the TIP peptide and airway epithelial cells. Numerous novel methods and single-molecule techniques were used to unravel: (i) how the TIP peptide interacts with the molecules on the apical side of the lung epithelial cells; (ii) whether the TIP peptide need to be internalized inside of the cells to trigger its effects; (iii) the nature of the interaction between the TIP peptide and its putative receptor(s); (iv) the putative receptor(s) for the TIP peptide on the apical surface of the lung epithelial cells.
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