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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Characterization of hyaluronan interactions with albumin
 Valentová, Kristýna ; Kratochvílová, Romana (referee) ; Chytil, Martin (advisor)
This bachelor thesis focuses on the research of physical interactions between hyaluronic acid and a protein albumin. In order to investigate these interactions following methods were used: pH and conductivity measurement, viscosimetry, turbidimetry and rheometry. The interactions were observed in solutions of fixed albumin concentration 1.0 gdm-3 and varying concentrations of hyaluronic acid from 0.1 to 2.0 gdm-3. Results were compared with a solution of hyaluronic acid without the addition of albumin. The results show that there are interactions between hyaluronic acid and albumin solutions, especially for those containing high molecular weight hyaluronic acid. The interactions exhibited a change in viscosity of solutions. We can see a reduction in viscosity after adding albumin to the reference solutions. The reduction is noticeable even in the low molecular weight HA solutions, but is not so significant.
Detailed record
Characterization of hyaluronan interactions with albumin
 Valentová, Kristýna ; Kratochvílová, Romana (referee) ; Chytil, Martin (advisor)
This bachelor thesis focuses on the research of physical interactions between hyaluronic acid and a protein albumin. In order to investigate these interactions following methods were used: pH and conductivity measurement, viscosimetry, turbidimetry and rheometry. The interactions were observed in solutions of fixed albumin concentration 1.0 gdm-3 and varying concentrations of hyaluronic acid from 0.1 to 2.0 gdm-3. Results were compared with a solution of hyaluronic acid without the addition of albumin. The results show that there are interactions between hyaluronic acid and albumin solutions, especially for those containing high molecular weight hyaluronic acid. The interactions exhibited a change in viscosity of solutions. We can see a reduction in viscosity after adding albumin to the reference solutions. The reduction is noticeable even in the low molecular weight HA solutions, but is not so significant.
Detailed record

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