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Neurological effects of endocrine disruptors
Ondráčková, Simona ; Brožka, Hana (advisor) ; Vítků, Jana (referee)
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Faktory ovlivňující kumulaci ftalátů v potravinách
Němečková, Tereza
The bachelor thesis Factors influencing phthalate accumulation in food has the character of a literature search and deals with factors that influence phthalate migration into food. Phthalates are lipophilic organic compounds that are used to soften plastics. As a result of human activities, they enter the environment, from which they subsequently enter the human food chain. However, food contamination also occurs during production and storage. Factors that influence the migration of phthalates into food include the contact time of the food with the polymer, storage temperature, ultrasound, pH of the food, UV radiation, type of preservative, and composition of the packaging material and food. Phthalates have negative effects on human and animal health. They cause reproductive disorders, allergic reactions, immune system disorders, cardiovascular problems and are carcinogenic.
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Determination of phtalates via GC-MS in children´s pacifiers and a risk of their transport to human´s digestive system.
CIHLÁŘOVÁ, Tereza
This bachelor thesis deals with the problems of phthalates analysis, or phthalic acid esters, contained in children´s pacifiers. These organic substances have been used for many years as a plasticizers of plastics, rubber and PVC. Since phthalates are not chemically bound in the polymers they are easily released into the environment. Phthalates have negative health effects on the human body, especially on the reproductive and endocrine system. Some phthalates behave in the body like xenoestrogens, mostly in males, since they can affect the development of genitals in infancy. A long-term intake of these substances leads to their accumulation in the organism, and thus there is a risk of developing chronic diseases. A long-term exposure to high doses over a long period of time increases the toxicity of the plasticisers, especially after a direct contact of young children with the pacifiers. The main aim of this bachelor thesis was description and assessment of the effects of phthalates on the human organism. Phthalates were determined by gas chromatography method with the mass spectrometric detection (GC-MS), after the extraction of plasticizers with an organic non-polar solvent. The phthalate analysis was conducted in two different parts of each baby pacifiers, that were randomly selected commercially available products. Phthalates were detected in most investigated samples, similar concentrations levels were found in both parts of the pacifiers.
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